[HTML][HTML] PPA1 regulates tumor malignant potential and clinical outcome of colon adenocarcinoma through JNK pathways

P Wang, Y Zhou, Q Mei, J Zhao, L Huang, Q Fu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) represents one of the most prevalent malignancies and the third
leading cause of cancer death worldwide. Inorganic pyrophosphatase (PPA1) is an enzyme …

Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer

T Niu, J Zhu, L Dong, P Yuan, L Zhang, D Liu - Cellular Signalling, 2023 - Elsevier
Colorectal cancer (CRC) is a common malignant tumor of the human digestive tract.
Inorganic pyrophosphatase 1 (PPA1) plays an imperative role in the advancement of …

PPA1 promotes NSCLC progression via a JNK-and TP53-dependent manner

D Luo, D Liu, W Shi, H Jiang, W Liu, X Zhang, Y Bao… - Oncogenesis, 2019 - nature.com
Inorganic pyrophosphatase (PPA1) promotes tumor progression in several tumor types.
However, the underlying mechanism remains elusive. Here, we disclosed that PPA1 …

[HTML][HTML] PPA1, an energy metabolism initiator, plays an important role in the progression of malignant tumors

S Wang, J Wei, S Li, Y Luo, Y Li, X Wang… - Frontiers in …, 2022 - frontiersin.org
Inorganic pyrophosphatase (PPA1) encoded by PPA1 gene belongs to Soluble
Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo …

[HTML][HTML] Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer

Y Yang, J Cai, J Yin, D Wang, Z Bai… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Inorganic pyrophosphatase (PPA1) is an enzyme which has been found to be upregulated
in various tumors, yet its profile in gastrointestinal cancers has not systemically investigated …

Clinical significance and functional validation of PPA1 in various tumors

D Luo, G Wang, W Shen, S Zhao, W Zhou… - Cancer …, 2016 - Wiley Online Library
The aim of the study was to detect PPA 1 expression in various tumors and to investigate the
relationship between PPA 1 expression and clinicopathological parameters to further …

Expression of inorganic pyrophosphatase (PPA1) correlates with poor prognosis of epithelial ovarian cancer

H Li, N Xiao, Z Li, Q Wang - The Tohoku journal of experimental …, 2017 - jstage.jst.go.jp
Ovarian serous carcinoma (OSC) is the most common epithelial ovarian cancer. Inorganic
pyrophosphatase (PPA1) catalyzes the hydrolysis of pyrophosphate to inorganic phosphate …

[HTML][HTML] Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway

H Niu, W Zhou, Y Xu, Z Yin, W Shen, Z Ye, Y Liu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Inorganic pyrophosphatase (PPA1) activity is a key determinant of cellular inorganic
pyrophosphate levels, and its expression is correlated with growth of several solid tumors …

[HTML][HTML] PPA1 promotes breast cancer proliferation and metastasis through PI3K/AKT/GSK3β signaling pathway

C Guo, S Li, A Liang, M Cui, Y Lou… - Frontiers in Cell and …, 2021 - frontiersin.org
Breast cancer is the most common malignancy among women. Inorganic pyrophosphatase
1 (PPA1) is a multifunctional protein involved in the development of several tumors …

[HTML][HTML] Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma

D Xu, Y Miao, X Gu, J Wang, G Yu - Oncology Letters, 2018 - spandidos-publications.com
The inorganic pyrophosphatase gene (PPA1) encodes inorganic pyrophosphatase, an
enzyme that catalyzes the hydrolysis of inorganic pyrophosphate to orthophosphate, and …