Follicle-stimulating hormone signaling is essential for the initiation and early stages of
spermatogenesis. Follicle-stimulating hormone receptor is exclusively expressed in Sertoli …

Spermatogenesis is contingent upon hormones and growth factors acting through endocrine
and paracrine pathways either in vivo or in vitro. Sertoli cells (SCs) furnish essential factors …

Testosterone and follicle-stimulating hormone (FSH) are required to obtain full reproductive
potential. In the testis, somatic Sertoli cells transduce signals from testosterone and FSH into …

The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

Spermatogenesis is a continuous and productive process supported by the self-renewal and
differentiation of spermatogonial stem cells (SSCs), which arise from undifferentiated …

Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in
regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited …

A complex milieu of hormones initiates diverse signaling pathways within and between cells
of the testis to support the processes of steroidogenesis, spermatogenesis, and ultimately …

The identification of the hormones and other factors regulating Sertoli cell survival,
proliferation, and maturation in neonatal, peripubertal, and pubertal life remains one of the …

Sertoli cells are the somatic cells of the testis that are essential for testis formation and
spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via …

FSH and testosterone exert different regulatory effects on the seminiferous epithelium; they
act through multiple and complex signaling routes to direct the development of the germ …