Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Melatonin is probably produced in all cells but is only secreted by the pineal gland. The
pineal secretion of melatonin is determined by the light–dark cycle, and it is only released at …

Melatonin (MT) is an endogenous hormone mainly synthesized by pineal cells, which has
strong endogenous effects of eliminating free radicals and resisting oxidative damages …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) is secreted during the dark hours at night
by pineal gland, and it regulates a variety of important central and peripheral actions related …

Oxidative stress has been recognized as one of the causal mediators of female infertility by
affecting the oocyte quality and early embryo development. Improving oxidative stress is …

In previous studies, oxidative stress damage has been solely considered to be the
mechanism of ovarian aging, and several antioxidants have been used to delay ovarian …

OBJECTIVE: To summarize the role of melatonin in the physiology and pathophysiology of
the ovary. DESIGN: Review of literature. SETTING: University Health Science Center …

This review summarizes new findings related to beneficial effects of melatonin (N-acetyl-5-
methoxytryptamine) on reproductive physiology. Recently many researchers have begun to …

With increase in women's age, the reproductive capability of female mammals decreases
dramatically caused by age-related oxidative stress, coinciding with the decline in the …

In recent years, the negative impact of oxidative stress on fertility has become widely
recognised. Several studies have demonstrated its negative effect on the number and …