There is growing evidence indicating the existence of a causal relationship between
abnormal airway smooth muscle (ASM) function and airway hyper-responsiveness, a poorly …

Bronchial asthma is characterized by airway inflammation, exaggerated airway narrowing to
bronchoconstrictor agonists, and attenuated beta-adrenoceptor-mediated airway relaxation …

Airway smooth muscle plays a pivotal role in modulating bronchomotor tone. Modulation of
contractile and relaxation signaling is critical to alleviate the airway hyperresponsiveness …

In addition to hyperresponsiveness in asthma, airway smooth muscle (ASM) also manifests
an inflammatory phenotype characterized by augmented expression of mediators that …

Airway hyperresponsiveness and obstruction are cardinal features of asthma. Compelling
evidence now suggests that the key features of asthma in part are due to intrinsic differences …

Asthma is characterized by the association of airway hyperresponsiveness (AHR),
inflammation, and remodelling. The aim of the present article is to review the pivotal role of …

Asthma is characterized in part by variable airflow obstruction and non-specific
hyperresponsiveness to a variety of bronchoconstrictors, both of which are mediated by the …

Introduction Asthma is characterized by enhanced airway contractility and remodeling where
airway smooth muscle (ASM) plays a key role, modulated by inflammation. Understanding …

Airway smooth muscle (ASM) plays a central role in regulating bronchomotor tone in
patients with asthma. New evidence, however, suggests that ASM may also orchestrate and …

The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and
constitutes an important target for treatment. These cells control muscle tone and thus …