Integrin αvβ3 is a cell adhesion molecule involved in the progression and invasion of
glioblastoma, making it an attractive target for the diagnosis of glioblastoma. Although some …

Integrin αvβ3 has been recognized to play an important role in angiogenesis, tumor growth
and metastasis. It will be of interest to apply this promising target for tumor imaging and …

This study sought to evaluate FITC-conjugated cyclic RGD peptides (FITC-RGD2, FITC-3P-
RGD2, and FITC-Galacto-RGD2) as fluorescent probes for in vitro assays of integrin …

In malignant gliomas, the integrin adhesion receptors seem to play a key role for invasive
growth and angiogenesis. However, there is still a controversy about the expression and the …

Page 2 of 5 proliferation and invasion (15). FAK and Src are downstream components of the
protein complex that couples the integrin β-cytoplasmic tail to the actin cytoskeleton that act …

In cancer cells integrins modulate important cellular events that regulate the metastasic
cascade which involves detachment from the tumor mass, dissemination and attachment to …

Integrins are expressed in tumor cells and tumor endothelial cells, and likely play important
roles in glioma angiogenesis and invasion. We investigated the anti‐glioma mechanisms of …

Recently, the research community has become increasingly concerned with the receptor
αvβ5, a member of the well-known integrin family. Different ongoing studies have evidenced …

Integrin αvβ3 is an adhesion molecule involved in tumor invasion, angiogenesis, and
metastasis. There is substantial interest in developing novel agents that bind to integrin …

Cilengitide is a cyclic peptide antagonist of integrins αvβ3 and αvβ5 that is currently being
evaluated as a novel therapeutic agent for recurrent and newly diagnosed glioblastoma. Its …