Poor penetration into the tumor parenchyma and the reduced therapeutic efficacy of
anticancer drugs and other medications are the major problems in tumor treatment. A new …

Background α3β1 integrin is a promising cancer biomarker and drug target. We previously
identified a 9-amino-acid cyclic peptide LXY30 for detecting α3β1 integrin on the surface of …

The interaction of a small library of cyclic RGD (Arg-Gly-Asp) peptidomimetics with αVβ6
integrin has been investigated by means of competitive solid phase binding assays to the …

Integrin αvβ3 plays great roles in tumor angiogenesis, invasion, and metastasis. We report
here the noninvasive visualization of tumor integrin αvβ3 expression by using near-infrared …

Radiolabeled peptides with high specificity for overexpressed receptors in tumor cells hold
great promise for diagnostic and therapeutic applications. In this work, we aimed at …

The tripeptide sequence arginine-glycine-aspartate (RGD) has been identified as the
common motif used by several endogenous ligands to recognise and bind a group of …

Central nervous system leukemia (CNS-L) is caused by leukemic cells infiltrating into the
meninges or brain parenchyma and remains the main reason for disease relapse. Currently …

Molecular imaging used in cancer diagnosis and therapeutic response monitoring is
important for glioblastoma (GBM) research. Antiangiogenic therapy currently is one of the …

Purpose Expression of cell adhesion molecule integrin α v β 3 is significantly up-regulated
during tumor growth, and sprouting of tumor vessels and correlates well with tumor …

Angiogenesis is a key physiological process that plays a key role in glioblastoma (GBM)
progression and displays therapeutic resistance to antiangiogenic therapies. In this study …