Delivery to mitochondria: a narrower approach for broader therapeutics

SS Malhi, RSR Murthy - Expert opinion on drug delivery, 2012 - Taylor & Francis
Introduction: Research has revealed a relationship between mitochondrial dysfunction and
diseases such as diabetes, ischemia–reperfusion injury, cancer and many more. As a result …

Drug delivery to mitochondria: the key to mitochondrial medicine

MP Murphy, RAJ Smith - Advanced drug delivery reviews, 2000 - Elsevier
The major function of mitochondria in human cells is to provide ATP by oxidative
phosphorylation. However, mitochondria have many other roles including the modulation of …

Power of mitochondrial drug delivery systems to produce innovative nanomedicines

Y Yamada, M Hibino, D Sasaki, J Abe… - Advanced Drug Delivery …, 2020 - Elsevier
Mitochondria carry out various essential functions including ATP production, the regulation
of apoptosis and possess their own genome (mtDNA). Delivering target molecules to this …

Mitochondrial drug delivery and mitochondrial disease therapy–an approach to liposome-based delivery targeted to mitochondria

Y Yamada, H Akita, K Kogure, H Kamiya, H Harashima - Mitochondrion, 2007 - Elsevier
Recent progress in genetics and molecular biology has provided useful information
regarding the molecular mechanisms associated with the mitochondrial diseases. Genetic …

[HTML][HTML] Advances in mitochondria-targeted drug delivery

E Bottani, D Brunetti - Pharmaceutics, 2023 - mdpi.com
Mitochondria are dynamic organelles that play a crucial role in numerous cellular activities.
Their primary function is to convert the energy stored in nutrients into adenosine …

Targeting mitochondria: strategies, innovations and challenges: the future of medicine will come through mitochondria

M Edeas, V Weissig - Mitochondrion, 2013 - Elsevier
Mitochondrial dysfunction has been associated with the aging process and a large variety of
human disorders, such as cardiovascular and neurodegenerative diseases, cancer …

[HTML][HTML] Editorial (thematic issue: mitochondrial biogenesis: pharmacological approaches)

T Valero - Current pharmaceutical design, 2014 - benthamdirect.com
Organelle biogenesis is concomitant to organelle inheritance during cell division. It is
necessary that organelles double their size and divide to give rise to two identical daughter …

Targeted drug delivery to mammalian mitochondria in living cells

V Weissig - Expert Opinion on Drug Delivery, 2005 - Taylor & Francis
Mitochondrial dysfunction causes or contributes to a large number of human disorders
including neuromuscular and neurodegenerative diseases, diabetes, ischaemia …

Mitochondria-targeted nanoparticles: a promising drug delivery system

L Liao, F Jin - Journal of Nanoscience and Nanotechnology, 2016 - ingentaconnect.com
A variety of diseases including neurodegenerative, neuromuscular diseases, diabetes,
obesity and cancer are considered to be caused by mitochondrial dysfunction. Efficient …

[HTML][HTML] The role of mitochondria in cellular toxicity as a potential drug target

D Wu, X Wang, H Sun - Cell biology and toxicology, 2018 - Springer
Mitochondrial malfunction is related to aging and to the onset of many diseases, such as
obesity/diabetes, cancer, and cardiovascular and neurodegenerative diseases. The …