Purpose To systematically assess test performance of patient‐adapted D‐dimer cut‐offs for
the diagnosis of venous thromboembolism (VTE). Methods Systematic review and analysis …

Objective To review the diagnostic accuracy of D-dimer testing in older patients (> 50 years)
with suspected venous thromboembolism, using conventional or age adjusted D-dimer cut …

Essentials• It is unclear if raising the D‐dimer level to exclude venous thrombosis in older
patients is valid.• We compared this 'age‐adjusted'strategy with other ways of interpreting D …

Background: The reported diagnostic accuracy of the D‐dimer test for exclusion of deep vein
thrombosis (DVT) and pulmonary embolism (PE) varies. It is unknown to what extent this is …

Two new strategies for interpreting D-dimer results have been proposed: i) using a
progressively higher D-dimer threshold with increasing age (age-adjusted strategy) and ii) …

Background As aging was found to be associated with increased D‐dimer levels, the
question arose whether D‐dimer measurement was useful in the diagnostic strategy of …

A State of the Art lecture titled “D-dimer Diagnostics: Can I use any D-dimer assay? Bridging
the Knowledge-to-Action gap” was presented at the International Society on Thrombosis and …

Renal impairment, a source of chronic hypercoagulability1 and inflammation, 2 is known to
reduce the specificity of the D-dimer test in the diagnosis of venous thromboembolism (VTE) …

Introduction Clinical algorithms consisting of pre-test probability estimation and D-dimer
testing are recommended in diagnostic work-up for suspected venous thromboembolism …

Background D-dimer testing has been widely used in the exclusion of venous
thromboembolism (VTE), but its clinical usefulness is limited in older patients because of a …