Patients with the Loeys‐Dietz syndrome (LDS) have mutations in the TGF‐βR1, TGF‐βR2,
and SMAD3 genes. However, little is known about the redox homeostasis in the thoracic …

Loeys–Dietz syndrome is an autosomal dominant genetic disorder which is associated with
significant and often crucial vascular manifestations. This review is aimed to examine current …

Loeys–Dietz syndrome (LDS) is caused by variants of transforming growth factor-β (TGF-β)-
related genes and is characterized by aortic aneurysm and dissection. We report an LDS …

Aim Thoracic aortic aneurysms are a life-threatening condition often diagnosed too late. To
discover novel robust biomarkers, we aimed to better understand the molecular mechanisms …

The role of oxidative stress in different aortopathies is evaluated. Thirty‐two tissue samples
from 18 men and 14 women were divided into: 4 control (C) subjects, 11 patients with …

Background: Aortic dilatation in Marfan syndrome (MFS) is progressive. It is associated with
oxidative stress and endothelial dysfunction that contribute to the early acute dissection of …

Loeys-Dietz syndrome (LDS) is a connective tissue disorder first described in 2005 featuring
aortic/arterial aneurysms, dissections, and tortuosity associated with craniofacial …

Abstract Background The Loeys-Dietz syndrome (LDS) is a rare autosomal dominant
disorder characterized by thoracic aortic aneurysm and dissection and widespread systemic …

The involvement of highly reactive oxygen-derived free radicals (ROS) in the genesis and
progression of various cardiovascular diseases, including arrhythmias, aortic dilatation …

Abstract Introduction Loeys-Dietz syndrome (LDS) is an autosomal dominant connective
tissue disorder due to heterozygous pathogenic variants in transforming growth factor beta …