[HTML][HTML] Metformin and its immune-mediated effects in various diseases
I Nojima, J Wada - International journal of molecular sciences, 2023 - mdpi.com
Metformin has been a long-standing prescribed drug for treatment of type 2 diabetes (T2D)
and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are …
and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are …
[HTML][HTML] Metformin as a potential agent in the treatment of multiple sclerosis
A Dziedzic, J Saluk-Bijak, E Miller, M Bijak - International Journal of …, 2020 - mdpi.com
Metformin, a synthetic derivative of guanidine, is commonly used as an oral antidiabetic
agent and is considered a multi-vector application agent in the treatment of other …
agent and is considered a multi-vector application agent in the treatment of other …
Metformin, a new era for an old drug in the treatment of immune mediated disease?
M Schuiveling, N Vazirpanah… - Current drug …, 2018 - ingentaconnect.com
Background: Metformin, a widely prescribed blood glucose normalizing antidiabetic drug, is
now beginning to receive increasing attention due to its anti-inflammatory properties …
now beginning to receive increasing attention due to its anti-inflammatory properties …
[HTML][HTML] Multifaceted mechanisms of action of metformin which have been unraveled one after another in the long history
H Kaneto, T Kimura, A Obata, M Shimoda… - International Journal of …, 2021 - mdpi.com
While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review
article, we focus on metformin which is an insulin sensitizer and is often used as a first …
article, we focus on metformin which is an insulin sensitizer and is often used as a first …
[HTML][HTML] Metformin in therapeutic applications in human diseases: Its mechanism of action and clinical study
Y Du, YJ Zhu, YX Zhou, J Ding, JY Liu - Molecular Biomedicine, 2022 - Springer
Metformin, a biguanide drug, is the most commonly used first-line medication for type 2
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …
[HTML][HTML] A clinical perspective of the multifaceted mechanism of metformin in diabetes, infections, cognitive dysfunction, and cancer
In type 2 diabetes, ecological and lifecourse factors may interact with the host microbiota to
influence expression of his/her genomes causing perturbation of interconnecting biological …
influence expression of his/her genomes causing perturbation of interconnecting biological …
[HTML][HTML] The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases
A Hasanvand - Inflammopharmacology, 2022 - Springer
Metformin can suppress gluconeogenesis and reduce blood sugar by activating adenosine
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …
Increased metformin dosage suppresses pro-inflammatory cytokine levels in systemic circulation and might contribute to its beneficial effects
ABSTRACT Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder, characterized by
persistent elevation of blood glucose either due to insulin resistance or insulin insufficiency …
persistent elevation of blood glucose either due to insulin resistance or insulin insufficiency …
Role of metformin in inflammation
YY Feng, Z Wang, H Pang - Molecular biology reports, 2023 - Springer
Background Metformin has good anti-hyperglycemic effectiveness, but does not induce
hypoglycemia, is very safe, and has become the preferred drug for the treatment of type 2 …
hypoglycemia, is very safe, and has become the preferred drug for the treatment of type 2 …
The intersection of metformin and inflammation
LP Bharath, BS Nikolajczyk - American Journal of …, 2021 - journals.physiology.org
The biguanide metformin is the most commonly used antidiabetic drug. Recent studies show
that metformin not only improves chronic inflammation by improving metabolic parameters …
that metformin not only improves chronic inflammation by improving metabolic parameters …