[HTML][HTML] Metformin and its immune-mediated effects in various diseases

I Nojima, J Wada - International journal of molecular sciences, 2023 - mdpi.com
Metformin has been a long-standing prescribed drug for treatment of type 2 diabetes (T2D)
and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are …

[HTML][HTML] Metformin as a potential agent in the treatment of multiple sclerosis

A Dziedzic, J Saluk-Bijak, E Miller, M Bijak - International Journal of …, 2020 - mdpi.com
Metformin, a synthetic derivative of guanidine, is commonly used as an oral antidiabetic
agent and is considered a multi-vector application agent in the treatment of other …

Metformin, a new era for an old drug in the treatment of immune mediated disease?

M Schuiveling, N Vazirpanah… - Current drug …, 2018 - ingentaconnect.com
Background: Metformin, a widely prescribed blood glucose normalizing antidiabetic drug, is
now beginning to receive increasing attention due to its anti-inflammatory properties …

[HTML][HTML] Multifaceted mechanisms of action of metformin which have been unraveled one after another in the long history

H Kaneto, T Kimura, A Obata, M Shimoda… - International Journal of …, 2021 - mdpi.com
While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review
article, we focus on metformin which is an insulin sensitizer and is often used as a first …

[HTML][HTML] Metformin in therapeutic applications in human diseases: Its mechanism of action and clinical study

Y Du, YJ Zhu, YX Zhou, J Ding, JY Liu - Molecular Biomedicine, 2022 - Springer
Metformin, a biguanide drug, is the most commonly used first-line medication for type 2
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …

[HTML][HTML] A clinical perspective of the multifaceted mechanism of metformin in diabetes, infections, cognitive dysfunction, and cancer

E Chow, A Yang, CHL Chung, JCN Chan - Pharmaceuticals, 2022 - mdpi.com
In type 2 diabetes, ecological and lifecourse factors may interact with the host microbiota to
influence expression of his/her genomes causing perturbation of interconnecting biological …

[HTML][HTML] The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases

A Hasanvand - Inflammopharmacology, 2022 - Springer
Metformin can suppress gluconeogenesis and reduce blood sugar by activating adenosine
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …

Increased metformin dosage suppresses pro-inflammatory cytokine levels in systemic circulation and might contribute to its beneficial effects

B Amoani, SA Sakyi, R Mantey, EF Laing… - … of immunoassay and …, 2021 - Taylor & Francis
ABSTRACT Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder, characterized by
persistent elevation of blood glucose either due to insulin resistance or insulin insufficiency …

Role of metformin in inflammation

YY Feng, Z Wang, H Pang - Molecular biology reports, 2023 - Springer
Background Metformin has good anti-hyperglycemic effectiveness, but does not induce
hypoglycemia, is very safe, and has become the preferred drug for the treatment of type 2 …

The intersection of metformin and inflammation

LP Bharath, BS Nikolajczyk - American Journal of …, 2021 - journals.physiology.org
The biguanide metformin is the most commonly used antidiabetic drug. Recent studies show
that metformin not only improves chronic inflammation by improving metabolic parameters …