A balancing act: The role of pro‐and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

LC Walker - Journal of neurochemistry, 2021 - Wiley Online Library
The central nucleus of the amygdala (CeA) is widely implicated as a structure that integrates
both appetitive and aversive stimuli. While intrinsic CeA microcircuits primarily consist of …

The role of the central amygdala in alcohol dependence

M Roberto, D Kirson, S Khom - Cold Spring …, 2021 - perspectivesinmedicine.cshlp.org
Alcohol dependence is a chronically relapsing disorder characterized by compulsive drug-
seeking and drug-taking, loss of control in limiting intake, and the emergence of a …

The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptides

M Roberto, NW Gilpin… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Alcohol dependence is a chronically relapsing disorder characterized by compulsive drug
seeking and drug taking, loss of control in limiting intake, and the emergence of a withdrawal …

The central amygdala as an integrative hub for anxiety and alcohol use disorders

NW Gilpin, MA Herman, M Roberto - Biological psychiatry, 2015 - Elsevier
The central amygdala (CeA) plays a central role in physiologic and behavioral responses to
fearful stimuli, stressful stimuli, and drug-related stimuli. The CeA receives dense inputs from …

Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence

NW Gilpin, M Roberto - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
Alcohol use disorders are characterized by compulsive drug-seeking and drug-taking, loss
of control in limiting intake, and withdrawal syndrome in the absence of drug. The central …

Inhibition of the amygdala: key to pathological states?

GJ Quirk, DR Gehlert - Annals of the New York Academy of …, 2003 - Wiley Online Library
The amygdala plays an important role in associating sensory stimuli with aversive or
appetitive outcomes. Conditioning procedures potentiate inputs to the amygdala, which …

Corticotropin-releasing factor (CRF) and neuropeptide Y (NPY): effects on inhibitory transmission in central amygdala, and anxiety-& alcohol-related behaviors

NW Gilpin - Alcohol, 2012 - Elsevier
The central amygdala (CeA) is uniquely situated to function as an interface between stress-
and addiction-related processes. This brain region has long been attributed an important …

Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking

LC Walker, LJ Hand, B Letherby, KL Huckstep… - …, 2021 - nature.com
The central nucleus of the amygdala (CeA) is a key hub of the neural circuitry regulating
alcohol and stress interactions. However, the exact neuronal populations that govern this …

Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene

SC Pandey - Trends in pharmacological sciences, 2003 - cell.com
It has been hypothesized that anxiety disorders play an important role in the initiation and
maintenance of alcohol drinking behaviors. However, the molecular mechanisms for the …

The center of the emotional universe: Alcohol, stress, and CRF1 amygdala circuitry

AE Agoglia, MA Herman - Alcohol, 2018 - Elsevier
The commonalities between different phases of stress and alcohol use as well as the high
comorbidity between alcohol use disorders (AUDs) and anxiety disorders suggest common …