The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Diabetic kidney disease (DKD) is one of the most common microvascular complication of
both type 1 (T1DM) and type 2 diabetes mellitus (T2DM), and the leading cause of end …

Increasing evidence suggests that epigenetic factors might regulate the complex interplay
between genes and the environment, and affect human diseases, such as diabetes and its …

Many clinical studies have shown that intensive glycemic control in patients with diabetes
can reduce the incidence and progression of diabetic nephropathy and can also reduce the …

The incidence of diabetes and its associated micro-and macrovascular complications is
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …

Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Diabetic vascular
complications such as DN can progress despite subsequent glycemic control, suggesting a …

Diabetes is associated with significantly accelerated rates of several debilitating
microvascular complications such as nephropathy, retinopathy, and neuropathy, and …

Poor metabolic control and host genetic predisposition are critical for diabetic kidney
disease (DKD) development. The epigenome integrates information from sequence …

Diabetic nephropathy (DN) is the most common cause for end stage renal disease (ESRD).
Next to environmental factors, genetic predispositions determine the susceptibility for DN …

Regulated gene expression by transcription factor networks is critical for normal kidney
function. Disruption of these complex networks leads to biochemical aberrations associated …