Diosmin: A Daboia russelii venom PLA2s inhibitor-purified, and characterized from Oxalis corniculata L medicinal plant

KS Kiran, VH Kameshwar, KKM Nagaraju… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Oxalis corniculata L is a medicinal plant that belongs to
the Oxalidaceae family. It is a little, slow-growing plant with a frail appearance typically found …

Action of Varespladib (LY-315920), a Phospholipase A2 Inhibitor, on the Enzymatic, Coagulant and Haemorrhagic Activities of Lachesis muta rhombeata (South …

PG Gutierres, DR Pereira, NL Vieira… - Frontiers in …, 2022 - frontiersin.org
Varespladib (VPL) was primarily developed to treat inflammatory disturbances associated
with high levels of serum phospholipase A2 (PLA2). VPL has also demonstrated to be a …

[PDF][PDF] Anti-venom potential of aqueous extract of stem bark of Mangifera indica L. against Daboia russellii (Russell's viper) venom

BL Dhananjaya, F Zameer, KS Girish, CJM DSouza - 2011 - researchgate.net
Several plant extracts rich in pharmacologically active compounds have shown to
antagonize venom of several species. Mangifera indica has been used against snakebite by …

The biflavonoid morelloflavone inhibits the enzymatic and biological activities of a snake venom phospholipase A2

JA Pereañez, AC Patiño, V Núñez, E Osorio - Chemico-biological …, 2014 - Elsevier
The biflavonoid morelloflavone has been reported as inhibitor of secretory PLA 2 s
(phospholipases A 2 from human synovial and bee venom sources); however, its capacity to …

Inactivation of Venom PLA2 Alleviates Myonecrosis and Facilitates Muscle Regeneration in Envenomed Mice: A Time Course Observation

H Xiao, H Li, D Zhang, Y Li, S Sun, C Huang - Molecules, 2018 - mdpi.com
Snake venom is a complex cocktail of toxins which induces a series of clinical and
pathophysiological manifestations in victims, including severe local tissue damage and …

Inhibitory effect of pinostrobin from Renealmia alpinia, on the enzymatic and biological activities of a PLA2

I Gómez-Betancur, JA Pereañez, AC Patiño… - International journal of …, 2016 - Elsevier
Pinostrobin is a flavanone isolated from Renealmia alpinia, a plant used in folk medicine to
treat snakebites. We tested the inhibitory ability of pinostrobin on the enzymatic …

Purification and partial characterization of an anticoagulant PLA2 from the venom of Indian Daboia russelii that induces inflammation through upregulation of …

A Deka, M Sharma, M Sharma… - … of Biochemical and …, 2017 - Wiley Online Library
The present study describes the purification and partial characterization of a basic
anticoagulant PLA2 enzyme named as Rv (i) PLA2 from the venom of Indian Daboia russelii …

Snake Venom PLA2s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules

BMA Carvalho, JDL Santos, BM Xavier… - BioMed Research …, 2013 - Wiley Online Library
Ophidian envenomation is an important health problem in Brazil and other South American
countries. In folk medicine, especially in developing countries, several vegetal species are …

Effects of morin on snake venom phospholipase A2 (PLA2)

CV Iglesias, R Aparicio, L Rodrigues-Simioni… - Toxicon, 2005 - Elsevier
Flavonoids are potent anti-inflammatory compounds isolated from several plant extracts, and
have been used experimentally against inflammatory processes. In this work, a PLA2 …

In silico and in vitro neutralization of PLA2 activity of Daboxin P by butein, mimosine and bakuchiol

A Devi, ND Namsa, R Doley - International Journal of Biological …, 2020 - Elsevier
Medicinal plants have always been used for snakebite treatment by traditional healers but
they lack scientific evidence of action. However secondary metabolites of such plants have …