Diosmin: A Daboia russelii venom PLA2s inhibitor-purified, and characterized from Oxalis corniculata L medicinal plant

KS Kiran, VH Kameshwar, KKM Nagaraju… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Oxalis corniculata L is a medicinal plant that belongs to
the Oxalidaceae family. It is a little, slow-growing plant with a frail appearance typically found …

Action of Varespladib (LY-315920), a Phospholipase A2 Inhibitor, on the Enzymatic, Coagulant and Haemorrhagic Activities of Lachesis muta rhombeata (South …

PG Gutierres, DR Pereira, NL Vieira… - Frontiers in …, 2022 - frontiersin.org
Varespladib (VPL) was primarily developed to treat inflammatory disturbances associated
with high levels of serum phospholipase A2 (PLA2). VPL has also demonstrated to be a …

Discovery of a new Daboia russelli viper venom PLA2 inhibitor using virtual screening of pharmacophoric features of co-crystallized compound

S Sukumaran, VM Prasanna, LK Panicker… - Journal of …, 2023 - Taylor & Francis
Snake venom PLA2, a member of the group of hydrolase enzymes, has been recognized as
a promising drug target for snake envenomation. In the present study, an attempt was made …

[PDF][PDF] Inhibition of secretary PLA2 - VRV-PL-VIIIa of Russell's viper venom by standard aqueous stem bark extract of Mangifera indica L.

BL Dhananjaya, S Sudarshan - 2015 - researchgate.net
The aqueous extract of Mangifera indica is known to possess anti-snake venom activities.
However, its inhibitory potency and mechanism of action on multi-toxic phospholipases A2s …

The biflavonoid morelloflavone inhibits the enzymatic and biological activities of a snake venom phospholipase A2

JA Pereañez, AC Patiño, V Núñez, E Osorio - Chemico-biological …, 2014 - Elsevier
The biflavonoid morelloflavone has been reported as inhibitor of secretory PLA 2 s
(phospholipases A 2 from human synovial and bee venom sources); however, its capacity to …

Inactivation of Venom PLA2 Alleviates Myonecrosis and Facilitates Muscle Regeneration in Envenomed Mice: A Time Course Observation

H Xiao, H Li, D Zhang, Y Li, S Sun, C Huang - Molecules, 2018 - mdpi.com
Snake venom is a complex cocktail of toxins which induces a series of clinical and
pathophysiological manifestations in victims, including severe local tissue damage and …

Purification and partial characterization of an anticoagulant PLA2 from the venom of Indian Daboia russelii that induces inflammation through upregulation of …

A Deka, M Sharma, M Sharma… - … of Biochemical and …, 2017 - Wiley Online Library
The present study describes the purification and partial characterization of a basic
anticoagulant PLA2 enzyme named as Rv (i) PLA2 from the venom of Indian Daboia russelii …

Inhibitory effect of pinostrobin from Renealmia alpinia, on the enzymatic and biological activities of a PLA2

I Gómez-Betancur, JA Pereañez, AC Patiño… - International journal of …, 2016 - Elsevier
Pinostrobin is a flavanone isolated from Renealmia alpinia, a plant used in folk medicine to
treat snakebites. We tested the inhibitory ability of pinostrobin on the enzymatic …

[PDF][PDF] Anti-venom potential of aqueous extract of stem bark of Mangifera indica L. against Daboia russellii (Russell's viper) venom

BL Dhananjaya, F Zameer, KS Girish, CJM DSouza - 2011 - nopr.niscpr.res.in
Several plant extracts rich in pharmacologically active compounds have shown to
antagonize venom of several species. Mangifera indica has been used against snakebite by …

Antiophidian properties of a dolastane diterpene isolated from the marine brown alga Canistrocarpus cervicornis

LDA Moura, EF Sanchez, ÉM Bianco… - … & Preventive Nutrition, 2011 - Elsevier
Snake venoms consist of a complex mixture, responsible for a wide range of biological
effects. Envenomation by Lachesis muta snake venom results in hemostatic disturbances …