TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

Transforming growth factor β (TGF-β) is a central mediator of fibrogenesis. TGF-β is
upregulated and activated in fibrotic diseases and modulates fibroblast phenotype and …

Transforming growth factor (TGF)-β is a prototypic multifunctional cytokine whose broad
modulatory mechanisms affect numerous biological functions both at the cell and organism …

Many chronic diseases are marked by fibrosis, which is defined by an abundance of
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of …

Transforming growth factor-β (TGF-β), a prototype of multifunctional cytokine, is a key
regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-β …

Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …

Recent advances in defining TGF-β signaling pathways have provided a new level of
understanding of the role of this pleiotropic growth factor in the development of fibrosis …

Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and
degradation. Excessive ECM deposition results in scarring and thickening of the affected …

Transforming growth factor-β (TGF-β) is widely recognized as a core pathway of fibrosis.
Inhibition of TGF-β signaling may thus offer potential for antifibrotic therapies. Long-term …

Transforming growth factor (TGF)-β uses several intracellular signaling pathways besides
canonical ALK5-Smad2/3 signaling to regulate a diverse array of cellular functions. Several …