Background Tyrosine hydroxylase (TH) catalyzes the rate-limiting step for the biosynthesis of
the catecholamines dopamine, noradrenaline and adrenaline. Although its distribution in …

Over the years, advances in immunohistochemistry techniques have been a critical step in
detecting and mapping neuromodulatory substances in the central nervous system. The …

The complex organization of brain regions during development requires a three-
dimensional approach to facilitate the visualization and quantification of dynamic changes …

Working on catecholamine systems for years, the neuropharmacologist Arvid Carlsson has
made a number of important and pioneering discoveries, which have highlighted the key …

Most of the studies on neurochemical mapping, connectivity and physiology in the
hypothalamic region were carried out in rats and under the columnar morphologic paradigm …

The purpose of the present investigation was to evaluate possible effects of severe prenatal
hypotrophy on the number and spatial distribution of tyrosine hydroxylase-immunoreactive …

Tyrosine hydroxylase-containing cells (TH cells) were investigated immunohistochemically
in early and late postembryonic zebrafish brain sections (at 2 and 5 days postfertilization …

Serotonin (5-HT)-synthetizing neurons, which are confined in the raphe nuclei of the
rhombencephalon, provide a pervasive innervation of the central nervous system (CNS) and …

An X-gal based histochemical assay was used to detect catecholamine (CA) cells in
transgenic mouse embryos, in which the expression of the lacZ reporter was driven by the …

We have examined the development of dopaminergic (DA) neurons in the embryonic
mesencephalon with regard to the expression of the gene coding for tyrosine hydroxylase …