[HTML][HTML] A Methodology for the Enzymatic Isolation of Embryonic Hypothalamus Tissue and Its Acute or Post-Culture Analysis by Multiplex Hybridisation Chain …

K Chinnaiya, M Placzek - Bio-protocol, 2023 - ncbi.nlm.nih.gov
The hypothalamus is an evolutionarily ancient part of the vertebrate ventral forebrain that
integrates the dialogue between environment, peripheral body, and brain to centrally govern …

Quantitative study of tyrosine hydroxylase protein levels within the somatic area of the rat locus coeruleus during postnatal development

L Bezin, D Marcel, C Rousset, JF Pujol… - Journal of …, 1994 - Soc Neuroscience
To date only global dosages of tyrosine hydroxylase (TH) protein have been realized in the
locus coeruleus (LC) without discriminating the enzyme contained in the cell body area from …

Neurophilic Descending Migration of Dorsal Midbrain Neurons Into the Hindbrain

CM García-Peña, D Ávila-González… - Frontiers in …, 2018 - frontiersin.org
Stereotypic cell migrations in the developing brain are fundamental for the proper patterning
of brain regions and formation of neural networks. In this work, we uncovered in the …

Ontogenesis of tyrosine hydroxylase-immunopositive structures in the rat hypothalamus. Fiber pathways and terminal fields

MV Ugrumov, A Tixier-Vidal, J Taxi, J Thibault… - Neuroscience, 1989 - Elsevier
The innervation of the hypothalamus and septal region by catecholaminergic fibers was
studied in rats from the 12th fetal day until the 9th postnatal day. Catecholaminergic fibers …

Altered expression of tyrosine hydroxylase in the locus coeruleus noradrenergic system in citalopram neonatally exposed rats and monoamine oxidase A knock out …

J Zhang, RD Darling, IA Paul, KL Simpson… - The Anatomical …, 2011 - Wiley Online Library
In rodents, noradrenergic (NE) locus coeruleus (LC) neurons are well known to express
tyrosine hydroxylase (TH) immunoreactivity. However, due to its very low enzyme activity …

Aminergic receptors during the development of the human brain: the contribution of in vitro imaging techniques

E del Olmo, A Pazos - Journal of Chemical Neuroanatomy, 2001 - Elsevier
The development of the human brain is a complex process and, in this regard, the
maturation of neurotransmitter systems and their receptors is of special interest. The study of …

Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine

AC Calvo, AL Pey, A Miranda-Vizuete… - Biochemical …, 2011 - portlandpress.com
TH (tyrosine hydroxylase) is the rate-limiting enzyme in the synthesis of catecholamines. The
cat-2 gene of the nematode Caenorhabditis elegans is expressed in mechanosensory …

The distribution of Dlx1-2 and glutamic acid decarboxylase in the embryonic and adult hypothalamus reveals three differentiated LHA subdivisions in rodents

M Barbier, S Croizier, G Alvarez-Bolado… - Journal of Chemical …, 2022 - Elsevier
The lateral hypothalamus (LHA) is still a poorly understood brain region. Based on
published Dlx and Gad gene expression patterns in the embryonic and adult hypothalamus …

Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission

K Nishii, N Matsushita, H Sawada… - Journal of …, 1998 - Wiley Online Library
Mice lacking expression of tyrosine hydroxylase (TH), the first and rate‐limiting enzyme of
the catecholamine biosynthetic pathway, in dopaminergic neuronal cell types were …

Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways

K Miyajima, C Kawamoto, S Hara… - Journal of Biological …, 2021 - ASBMB
Dopamine (DA) exerts well-known functions in the brain as a neurotransmitter. In addition, it
plays important physiological roles in peripheral organs, but it is largely unknown how and …