Background: Hyperpolarized 13 C spectroscopic magnetic resonance spectroscopy (MRS)
is an advanced imaging tool that may provide important real-time information about brain …

Transient expression of tyrosine hydroxylase (TH, the first enzyme in catecholamine
synthesis) has been shown in different brain and peripheral structures of various species …

The ability to study the characteristics of serotonin release from human serotonergic neurons
is valuable both in terms of understanding disease pathology and in trying to understand …

Immunohistochemistry using antibodies to tyrosine hydroxylase (TH), a rate-limiting enzyme
which catalyzes the initial step in the catecholamine synthesizing pathway, has been widely …

Transgenic mouse lines in which a fluorescent protein is constitutively expressed under the
Thy1 gene promoter have become important models in cell biology and pathology studies of …

Early life stressors have life-long functional and anatomical consequences. Though many
neurotransmitters are involved in the functional impact of early life stress, dopamine seems …

The major catecholamines—dopamine (DA) and norepinephrine (NE)—are not only
involved in synaptic communication but also act as important trophic factors and might …

The hypothalamus is the region of the brain in charge of homeostasis as well as homeostatic
behaviors like eating and drinking. The anatomical, connectional and physiological …

We present a robust, fresh-frozen approach to immunohistochemistry (IHC), without
committing the tissue to IHC via fixation and cryopreservation while maintaining long-term …

Thyroid hormone (TH) is essential for brain development. While disruption of TH signaling
by environmental chemicals has been discussed as a mechanism of developmental …