The propagation of epileptiform events is a highly interesting phenomenon from the
pathophysiological point of view, as it involves several mechanisms of recruitment of neural …

Recurrent, spontaneous seizure activity caused by abnormal neuronal firing in the brain is a
hallmark of epilepsy, a common chronic neurological disorder. Recent research that has …

Epileptic seizures are paroxysmal clinical events arising from neuronal hyperexcitability and
hypersynchrony of the cerebral cortex, either locally or simultaneously in both hemispheres …

Antiepileptic drugs (AEDs) are designed to prevent and suppress seizure activity. Their
effects on calcium influx and molecular cascades contributing to necrotic and apoptotic …

Opinion statement Seizure aggravation by antiepileptic drugs (AEDs) is an overestimated
phenomenon. While it undoubtedly occurs, the quality of evidence in most published reports …

In spite of numerous case reports and of a growing interest, there is a paucity of information
on seizure worsening by antiepileptic drugs (AEDs) in both adults and children with …

Over the decades, various interventions have been developed and utilized to treat epilepsy.
However, the majority of epileptic patients are often first prescribed anti-epileptic drugs …

Recent discoveries in molecular biology and human genetics have contributed greatly to an
understanding of the nature of seizure (ictal) activity. However, two questions of fundamental …

The mechanisms of epileptic discharge generation and spread are not yet fully known. A
recently proposed simple biophysical model of interictal and ictal discharges, Epileptor-2 …

Purpose: Although the paradoxical ability of anti‐epileptic drugs (AEDs) to increase seizure
activity has been recognized for decades, the underlying mechanisms are poorly …