Cardiac remodeling occurs frequently in chronic kidney disease patients and affects quality
of life and survival. Current treatment options are highly inadequate. As kidney function …

Chronic kidney disease (CKD) affects millions of people globally and, for most patients, the
risk of developing cardiovascular disease is higher than that of progression to kidney failure …

The pathophysiology of vascular disease is linked to accelerated biological aging and a
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …

Impaired renal function with loss of nephron number in chronic renal disease (CKD) is
associated with increased cardiovascular morbidity and mortality. However, the structural …

Over the past decade, science has greatly advanced our understanding of interdependent
feedback mechanisms involving the heart, lung, and kidney. Organ injury is the …

Chronic kidney disease (CKD) and cardiac insufficiency often co-exist, particularly in uremic
patients on hemodialysis (HD). The occurrence of abnormal renal function in patients with …

Synthesis of transmembrane and secretory proteins occurs within the endoplasmic reticulum
(ER) and is extremely important in the normal functioning of both the heart and kidney. The …

Cardiovascular diseases (CVDs), especially those involving a systemic inflammatory
process such as atherosclerosis, remain the leading cause of morbidity and mortality in …

Systemic inflammation in end-stage renal disease is an established risk factor for mortality
and a catalyst for other complications, which are related to a premature aging phenotype …

Patients with chronic kidney disease (CKD) exhibit an elevated cardiovascular risk
manifesting as coronary artery disease, heart failure, arrhythmias, and sudden cardiac …