Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS
Fragments of hyaluronan released after injury bind and activate TLR4 in a complex with
CD44. Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters …
CD44. Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters …
[HTML][HTML] Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2
KR Taylor, K Yamasaki, KA Radek, A Di Nardo… - Journal of Biological …, 2007 - ASBMB
Inflammation under sterile conditions is not well understood despite its importance in trauma
and autoimmune disease. To investigate this process we established mouse models of …
and autoimmune disease. To investigate this process we established mouse models of …
Hyaluronan as an immune regulator in human diseases
Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
CD44 suppresses TLR-mediated inflammation
H Kawana, H Karaki, M Higashi, M Miyazaki… - The Journal of …, 2008 - journals.aai.org
The cell adhesion molecule CD44, which is the major hyaluronan receptor, has been
implicated in the binding, endocytosis, and metabolism of hyaluronan. Previous studies …
implicated in the binding, endocytosis, and metabolism of hyaluronan. Previous studies …
CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages
CD44 is a transmembrane adhesion molecule and hemopoietic CD44 has an essential role
in hyaluronan clearance and resolution of noninfectious lung injury. In this study, we …
in hyaluronan clearance and resolution of noninfectious lung injury. In this study, we …
[HTML][HTML] Differential use of chondroitin sulfate to regulate hyaluronan binding by receptor CD44 in inflammatory and interleukin 4-activated macrophages
B Ruffell, GFT Poon, SSM Lee, KL Brown… - Journal of Biological …, 2011 - ASBMB
CD44 is a cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan
and is involved in processes ranging from leukocyte recruitment to wound healing. In the …
and is involved in processes ranging from leukocyte recruitment to wound healing. In the …
Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation
SM Ruppert, TR Hawn, A Arrigoni, TN Wight… - Immunologic …, 2014 - Springer
The extracellular matrix polysaccharide hyaluronan (HA) exerts size-dependent effects on
leukocyte behavior. Low-molecular weight HA is abundant at sites of active tissue …
leukocyte behavior. Low-molecular weight HA is abundant at sites of active tissue …
Hyaluronan receptors involved in cytokine induction in monocytes
H Yamawaki, S Hirohata, T Miyoshi, K Takahashi… - …, 2009 - academic.oup.com
During inflammation, lower molecular weight fragments of hyaluronan accumulate, and this
is known to be inflammatory and immune-stimulatory. In diseases such as inflammatory …
is known to be inflammatory and immune-stimulatory. In diseases such as inflammatory …
Hyaluronan in tissue injury and repair
A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …
Hyaluronan induces cell death in activated T cells through CD44
In the immune system, leukocyte activation induces CD44 to bind hyaluronan, a component
of the extracellular matrix. Here we used gain and loss of hyaluronan-binding mutants of …
of the extracellular matrix. Here we used gain and loss of hyaluronan-binding mutants of …