Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies?

JT Ito, JD Lourenço, RF Righetti, IFLC Tibério… - Cells, 2019 - mdpi.com
Changes in extracellular matrix (ECM) components in the lungs are associated with the
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …

The extracellular matrix–the under‐recognized element in lung disease?

JK Burgess, T Mauad, G Tjin, JC Karlsson… - The Journal of …, 2016 - Wiley Online Library
The lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM)
contains the main building blocks of both components. The ECM provides physical support …

[HTML][HTML] Chronic lung diseases: entangled in extracellular matrix

JK Burgess, MC Harmsen - European Respiratory Review, 2022 - Eur Respiratory Soc
The extracellular matrix (ECM) is the scaffold that provides structure and support to all
organs, including the lung; however, it is also much more than this. The ECM provides …

Lung extracellular matrix and fibroblast function

ES White - Annals of the American Thoracic Society, 2015 - atsjournals.org
Extracellular matrix (ECM) is a tissue-specific macromolecular structure that provides
physical support to tissues and is essential for normal organ function. In the lung, ECM plays …

Extracellular matrix in lung development, homeostasis and disease

Y Zhou, JC Horowitz, A Naba, N Ambalavanan… - Matrix Biology, 2018 - Elsevier
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …

Extracellular matrix as a driver of progressive fibrosis

J Herrera, CA Henke… - The Journal of clinical …, 2018 - Am Soc Clin Investig
The extracellular matrix (ECM) is dynamically tuned to optimize physiological function. Its
major properties, including composition and mechanics, profoundly influence cell biology …

Extracellular matrix remodelling in COPD

M Karakioulaki, E Papakonstantinou… - European Respiratory …, 2020 - Eur Respiratory Soc
The extracellular matrix (ECM) of the lung plays several important roles in lung function, as it
offers a low resistant pathway that allows the exchange of gases, provides compressive …

Disorders of lung matrix remodeling

HA Chapman - The Journal of clinical investigation, 2004 - Am Soc Clin Investig
A set of lung diseases share the tendency for the development of progressive fibrosis
ultimately leading to respiratory failure. This review examines the common pathogenetic …

Extracellular matrix injury during lung inflammation

EJ Campbell, RM Senior, HG Welgus - Chest, 1987 - journal.chestnet.org
Irreversible abnormalities of lung architecture are hallmarks of many acute and chronic
diseases. Lung cavities in gram-negative bacterial pneumonias and pulmonary tuberculosis …

Matrix remodeling in pulmonary fibrosis and emphysema

T Kulkarni, P O'Reilly, VB Antony, A Gaggar… - American journal of …, 2016 - atsjournals.org
Pulmonary fibrosis and emphysema are chronic lung diseases characterized by a
progressive decline in lung function, resulting in significant morbidity and mortality. A …