Background/Aim: Efficient delivery of siRNA is critical for its therapeutic applications. This
study was aimed at the design, synthesis and evaluation of a novel delivery system based …

Biodegradable disulfide-containing polyethyleneimine (PEI) derivatives showed great
potential as siRNA vectors for the treatment of cancer due to the reduction-sensitive …

Background/Aim: Effective and targeted delivery of siRNA to tumor cells is a prerequisite to
achieving their therapeutic effects. Survivin is up-regulated in tumor cells and is associated …

As a gene delivery method in breast cancer therapy, knocking down the undesired genes in
the cancerous cells would be promising. Inhibitors of Apoptosis Protein (IAP) family genes …

The limited effectiveness of the conventional methods for cancer treatment makes the
researchers to find novel safe and effective therapeutic strategies. One of these strategies is …

Nanoparticle-mediated small interfering RNA (siRNA) delivery is a promising therapeutic
strategy in various cancers. However, it is difficult to deliver degradative siRNA to tumor …

In recent years, gene therapy has drawn great attention in the field of cancer treatment for
high efficacy, selectivity, and few adverse effects. Many vectors have been developed for …

Here, polyethylenimine (PEI) modified silk fibroin nanoparticles (SFNPs) were prepared for
codelivery of doxorubicin (DOX) and survivin siRNA. The prepared NPs were characterized …

Delivery of small interfering RNAs (siRNAs) into cells still remains a challenge in gene
delivery studies. Here, we investigated the ability of synthesized Fe 3 O 4-PEG-LAC …

Gene therapy has been one of potential strategies for the treatment of different diseases,
where efficient and safe gene delivery systems are also extremely in need. Current LNP …