Despite enormous efforts in treating myocardial infarction (MI) and subsequent heart failure,
the recent statistics from the American Heart Association evidently show that there still …

INTRODUCTION: Progress in cardiovascular regenerative medicine research requires the
availability of appropriate experimental animal models that are as close to humans as …

A number of promising therapies for ischemic cardiomyopathy are emerging, and the role of
translational research in testing the efficacy and safety of these agents in relevant clinical …

Introduction of newly discovered cardiovascular therapeutics into first-in-man trials depends
on a strictly regulated ethical and legal roadmap. One important prerequisite is a good …

Sustainable and reproducible large animal models that closely replicate the clinical
sequelae of myocardial infarction (MI) are important for the translation of basic science …

Background Most animal studies on myocardial infarction (MI) have used open-chest
models with direct surgical coronary artery ligation, which imply local as well as generalized …

INTRODUCTION: The aim of this study was to develop a percutaneous, low risk, and
reproducible technique of MI that simulates human disease. METHODS: MI was induced in …

Objectives: The aim of this study is to evaluate a catheter‐based porcine model for
reperfused myocardial infarction and investigate the appropriate location and duration of the …

Cardiac pathologies are among the leading causes of mortality and morbidity in
industrialized countries, with myocardial infarction (MI) representing one of the major …

There are few stable and reproducible large-animal models of chronic heart failure
produced by ischaemic damage to the myocardium. Here we characterize a novel method of …