Background Some patients develop breakthrough psychotic symptoms on antipsychotic
maintenance medication (BAMM), despite receiving therapeutic antipsychotic doses to …

Antipsychotic drugs are highly effective in preventing relapse among individuals with
schizophrenia, with a number needed to treat of 3. 1 Suboptimal adherence with …

BackgroundThere is uncertainty about the incidence of breakthrough psychosis in treatment
adherent patients, and the role that factors, such as cumulative antipsychotic exposure, play …

Background The long-term consequences of discontinuing antipsychotic medication after
successful treatment of first-episode psychosis are not well studied. We assess the relation …

Background Most individuals with schizophrenia-spectrum disorders have relapses, which
increase the risk of morbidity and mortality. Because non-adherence to antipsychotic …

Individuals experiencing a first episode of psychosis are likely to respond well to treatment
with antipsychotic medications. Of those treated for a first episode of schizophrenia, three out …

Background Several national guidelines recommend continuous use of antipsychotic
medication after a psychotic episode in order to minimize the risk of relapse. However some …

Psychotic exacerbation is undesirable for any patient, but it is particularly important to
prevent psychotic exacerbations for recent-onset patients. Early relapse may disrupt …

The large majority of individuals with a first episode of schizophrenia will experience a
remission of symptoms within their first year of treatment. It is not clear how long treatment …

Background There is uncertainty about the required duration of long-term antipsychotic
maintenance medication after a first episode of psychosis. Robust predictors of relapse after …