Activated hepatic stellate cells (HSCs) is a key event in the progression of liver fibrosis.
HSCs transdifferentiate into myofibroblasts and secrete large amounts of extracellular …

The differentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in liver
fibrosis. Due to the local stiffening of the extracellular matrix (ECM) during fibrosis, it is of …

Hepatic stellate cells (HSCs) play an important role in liver fibrosis; however, owing to the
heterogeneity and limited supply of primary HSCs, the development of in vitro liver fibrosis …

Chronic liver disease is a major cause of morbidity and mortality worldwide marked by
chronic inflammation and fibrosis/scarring, resulting in end-stage liver disease and its …

Liver fibrosis occurs in most cases of chronic liver disease, which are somewhat common,
but also a potentially deadly group of diseases. In vitro modeling of liver fibrosis relies …

Liver fibrosis is a common feature of progressive liver disease and is manifested as a
dynamic series of alterations in both the biochemical and biophysical properties of the liver …

The hallmark of liver fibrosis is excessive extracellular matrix (ECM) synthesis and
deposition that improve liver matrix remodeling and stiffening. Increased matrix stiffness is …

The fibrogenic wound-healing response in liver increases stiffness. Stiffness
mechanotransduction, in turn, amplifies fibrogenesis. Here, we aimed to understand the …

Hepatic fibrosis is a key feature of progressive liver disease and an important therapeutic
target. Hepatic stellate cells (HSCs) are activated by damage-related stimuli, which promote …

Over the past few decades, extensive research has explored the development of supportive
scaffold materials for in vitro hepatic cell culture, to effectively mimic in vivo …