In situ regulation and mechanisms of 3D matrix stiffness on the activation and reversion of hepatic stellate cells
G Chen, Y Deng, B Xia, Y Lv - Advanced Healthcare Materials, 2023 - Wiley Online Library
Activated hepatic stellate cells (HSCs) is a key event in the progression of liver fibrosis.
HSCs transdifferentiate into myofibroblasts and secrete large amounts of extracellular …
HSCs transdifferentiate into myofibroblasts and secrete large amounts of extracellular …
Hydrogels with differential and patterned mechanics to study stiffness-mediated myofibroblastic differentiation of hepatic stellate cells
M Guvendiren, M Perepelyuk, RG Wells… - Journal of the mechanical …, 2014 - Elsevier
The differentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in liver
fibrosis. Due to the local stiffening of the extracellular matrix (ECM) during fibrosis, it is of …
fibrosis. Due to the local stiffening of the extracellular matrix (ECM) during fibrosis, it is of …
In vitro modeling of liver fibrosis with 3D co‐culture system using a novel human hepatic stellate cell line
HJ Lee, SJ Mun, CR Jung, HM Kang… - Biotechnology and …, 2023 - Wiley Online Library
Hepatic stellate cells (HSCs) play an important role in liver fibrosis; however, owing to the
heterogeneity and limited supply of primary HSCs, the development of in vitro liver fibrosis …
heterogeneity and limited supply of primary HSCs, the development of in vitro liver fibrosis …
Engineering in vitro models of hepatofibrogenesis
Chronic liver disease is a major cause of morbidity and mortality worldwide marked by
chronic inflammation and fibrosis/scarring, resulting in end-stage liver disease and its …
chronic inflammation and fibrosis/scarring, resulting in end-stage liver disease and its …
Differential fibrotic phenotypes of hepatic stellate cells within 3D liver organoids
M Brovold, D Keller, S Soker - Biotechnology and …, 2020 - Wiley Online Library
Liver fibrosis occurs in most cases of chronic liver disease, which are somewhat common,
but also a potentially deadly group of diseases. In vitro modeling of liver fibrosis relies …
but also a potentially deadly group of diseases. In vitro modeling of liver fibrosis relies …
High throughput interrogation of human liver stellate cells reveals microenvironmental regulation of phenotype
A Brougham-Cook, I Jain, DA Kukla, F Masood… - Acta biomaterialia, 2022 - Elsevier
Liver fibrosis is a common feature of progressive liver disease and is manifested as a
dynamic series of alterations in both the biochemical and biophysical properties of the liver …
dynamic series of alterations in both the biochemical and biophysical properties of the liver …
[HTML][HTML] Matrix mechanics as regulatory factors and therapeutic targets in hepatic fibrosis
G Chen, B Xia, Q Fu, X Huang, F Wang… - International journal of …, 2019 - ncbi.nlm.nih.gov
The hallmark of liver fibrosis is excessive extracellular matrix (ECM) synthesis and
deposition that improve liver matrix remodeling and stiffening. Increased matrix stiffness is …
deposition that improve liver matrix remodeling and stiffening. Increased matrix stiffness is …
Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis
The fibrogenic wound-healing response in liver increases stiffness. Stiffness
mechanotransduction, in turn, amplifies fibrogenesis. Here, we aimed to understand the …
mechanotransduction, in turn, amplifies fibrogenesis. Here, we aimed to understand the …
Delineating the role of angiogenesis in liver fibrosis
H Thomas - Nature Reviews Gastroenterology & Hepatology, 2018 - nature.com
Hepatic fibrosis is a key feature of progressive liver disease and an important therapeutic
target. Hepatic stellate cells (HSCs) are activated by damage-related stimuli, which promote …
target. Hepatic stellate cells (HSCs) are activated by damage-related stimuli, which promote …
The impact of matrix stiffness on hepatic cell function, liver fibrosis, and hepatocellular carcinoma—Based on quantitative data
K Min, SK Karuppannan, G Tae - Biophysics Reviews, 2024 - pubs.aip.org
Over the past few decades, extensive research has explored the development of supportive
scaffold materials for in vitro hepatic cell culture, to effectively mimic in vivo …
scaffold materials for in vitro hepatic cell culture, to effectively mimic in vivo …