Ezrin regulates synovial angiogenesis in rheumatoid arthritis through YAP and Akt signalling

Q Chen, K Fan, X Chen, X Xie, L Huang… - Journal of Cellular …, 2021 - Wiley Online Library
This study aimed to investigate the role and regulatory mechanisms of Ezrin in synovial
vessels in rheumatoid arthritis (RA). Synovial tissues were obtained from people with …

Increased phosphorylation of ezrin is associated with the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis

Y Xiao, M Sun, Z Zhan, Y Ye, M Huang, Y Zou… - …, 2014 - academic.oup.com
Objective. Increasing evidence indicates that the cytoskeletal protein ezrin may play a critical
role in cell motility. This study aims to investigate the role of ezrin in regulating the migration …

Knockdown of ezrin suppresses the migration and angiogenesis of human umbilical vein endothelial cells in vitro

L Zhao, L Huang, X Tian, F Liang, J Wei… - Journal of Huazhong …, 2016 - Springer
Progressive tumor growth is dependent on angiogenesis. The mechanisms by which
endothelial cells (ECs) are incorporated to develop new blood vessels are not well …

Increased phosphorylation of ezrin/radixin/moesin proteins contributes to proliferation of rheumatoid fibroblast-like synoviocytes

H Huang, Y Xiao, H Lin, D Fu, Z Zhan, L Liang… - …, 2011 - academic.oup.com
Objectives. Increasing evidence indicates that ezrin/radixin/moesin (ERM) proteins may play
a critical role in cell proliferation. This study examined the role of ERM proteins in …

Ezrin promotes invasion and migration of the MG63 osteosarcoma cell

J Zhang, J Zuo, M Lei, S Wu, X Zang… - Chinese medical …, 2014 - journals.lww.com
Background Evidence shows that ezrin plays an important role in the development of some
human malignancies. But the mechanism by which ezrin may affect tumor cell invasion and …

MiR-613 inhibits proliferation and invasion and induces apoptosis of rheumatoid arthritis synovial fibroblasts by direct down-regulation of DKK1

L Liu, Y Zuo, Y Xu, Z Zhang, Y Li, J Pang - Cellular & molecular biology …, 2019 - Springer
Background This study aimed to investigate the effects of miR-613 on the proliferation,
invasion and apoptosis of rheumatoid arthritis synovial fibroblasts (RASFs). Methods …

Ezrin promotes pancreatic cancer cell proliferation and invasion through activating the Akt/mTOR pathway and inducing YAP translocation

C Quan, J Sun, Z Lin, T Jin, B Dong… - Cancer Management …, 2019 - Taylor & Francis
Background Ezrin and YAP are abnormally expressed in various cancers, and play pivotal
roles in cancer initiation and development. However, the mechanisms of Ezrin in pancreatic …

Bidirectional tumor-promoting activities of macrophage ezrin

K Khan, B Long, GM Deshpande, PL Fox - International Journal of …, 2020 - mdpi.com
Ezrin links the cytoskeleton to cell surface integrins and plasma membrane receptors,
contributing to the proliferative and metastatic potential of cancer cells. Elevated ezrin …

The effects of miR-26b-5p on fibroblast-like synovial cells in rheumatoid arthritis (RA-FLS) via targeting EZH2

P Hu, ZS Dong, S Zheng, X Guan, L Zhang, L Li, Z Liu - Tissue and Cell, 2021 - Elsevier
Objective To study the possible effects of miR-26b-5p on fibroblast-like synovial cells in
rheumatoid arthritis (RA-FLS) through targeting enhancer of zeste homolog 2 (EZH2) …

YAP/TAZ: key players for rheumatoid arthritis severity by driving fibroblast like synoviocytes phenotype and fibro-inflammatory response

R Caire, E Audoux, G Courbon, E Michaud… - Frontiers in …, 2021 - frontiersin.org
Objective The role of YAP/TAZ, two transcriptional co-activators involved in several cancers,
was investigated in rheumatoid arthritis (RA). Methods Fibroblast like synoviocytes (FLS) …