Objective The purpose of our study was to elucidate the impact of microRNA-126 (miR-126)
targeting PIK3R2 gene on cell proliferation and apoptosis of rheumatoid arthritis synovial …

Background Ezrin is a member of the ezrin, radixin, and moesin family that provides a
functional link between the plasma membrane and the cortical actin cytoskeleton. A …

Metastatic prostate cancer (PCa) remains incurable and fatal. Previous studies have proven
that circulating tumor cells (CTCs) and Ezrin are involved in PCa progression, metastasis …

The overgrowth of synovial tissues is critical in the pathogenesis of rheumatoid arthritis (RA).
The expression of Synoviolin (SYN), an E3 ubiquitin ligase, is upregulated in arthritic …

Objective To evaluate the role of the MEK/ERK MAP kinase pathway in murine collagen‐
induced arthritis (CIA) using the selective MEK inhibitor PD184352. We examined the effects …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by abnormal
inflammation, angiogenesis, and cartilage destruction. Our previous study demonstrated an …

Dysregulation of miRNAs in chondrocytes has been confirmed to participate in osteoarthritis
(OA) progression. Previous study has screen out several key miRNAs may play crucial role …

In the previous issue of Trends in Molecular Medicine, Kent Hunter discussed the potential
effects of ezrin in tumor metastasis [1]. In his article, two recent papers were described …

Background Ezrin, a member of the ezrin-radixin-moesin family, is implicated in tumor
progression, metastatic dissemination, and adverse outcomes, in several cancer types. In …

It has been established that hyaluronic acid (HA) glycans (nHA) and oligosaccharide (oHA)
exert different effects on the biological function of the vascular endothelial cell (EC), resulting …