Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …

The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration
as a result of the aging process. Melatonin is considered to be an anti-aging agent …

Female fertility irreversibly declines with aging, and this is primarily associated with the
decreased quality and quantity of oocytes. To evaluate whether a long‐term of melatonin …

Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin
is considered an anti‐aging agent due to its cytoprotective actions as an antioxidant. This …

In the field of assisted reproductive technology, female fertility preservation, particularly
ovarian tissue cryopreservation in adolescent cancer patients, has attracted much attention …

Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Objective: To establish an oxidative stress-induced model of premature ovarian insufficiency
(POI) and to explore the effect of SIRT1 and mitochondrial oxidative phosphorylation on the …

In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …

Aims Previous reports have demonstrated that melatonin exists in multiple extrapineal sites,
and higher amounts of melatonin are present in human follicular fluid than in serum, which …

Loss of follicles together with decreased oocyte quality and quantity contribute to age-
associated ovarian senescence and infertility. Although underlying mechanisms for ovarian …