Oxidative stress is known as a major contributing factor involved in oocyte aging, which
negatively affects oocyte quality and development after fertilization. Melatonin is an effective …

Oxidative stress has been recognized as one of the causal mediators of female infertility by
affecting the oocyte quality and early embryo development. Improving oxidative stress is …

Melatonin confers protective effects on premature ovarian insufficiency (POI) induced by
tripterygium glycosides (TG) by reducing oxidative stress. Silent information regulator 1 …

Oxidative stress generates a large amount of reactive oxygen species (ROS) and affects
sperm quality via damaging sperm DNA and compromising the intracellular homeostasis in …

If fertilization does not occur for a prolonged period in vivo or in vitro, the postovulatory
oocytes will deteriorate, which called the postovulatory aging. This process disrupts the …

Emerging evidence has demonstrated that melatonin (MT) plays a crucial role in regulating
mammalian reproductive functions. It has been reported that MT has a protective effect on …

Sudan I is one of the industry dyes and widely used in cosmetics, wax agent, solvent and
textile. Sudan I has multiple toxicity such as carcinogenicity, mutagenicity, genotoxicity and …

Mitochondrial injury in granulosa cells (GCs) is associated with the pathophysiological
mechanism of polycystic ovary syndrome (PCOS). Melatonin reduces the mitochondrial …

Background Ovarian function is closely related to the degree of vascular network
development surrounding the ovary. Maternal aging‐related construction defects in this …

Studies have shown that melatonin (MLT) can delay ovarian aging, but the mechanism has
not been fully elucidated. Here we show that granulosa cells isolated from mice follicles can …