Nimotuzumab combined with irradiation enhances the inhibition to the HPV16 E6-promoted growth of cervical squamous cell carcinoma

Z Xu, H Shu, F Zhang, W Luo, Y Li, J Chu… - Frontiers in …, 2020 - frontiersin.org
Human papillomavirus (HPV) 16 E6 has been proved to increase the radiosensitivity and
lead to the EGFR overexpression in cervical cancer cells. In this study, to investigate the …

E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer

EL Morgan, JA Scarth, MR Patterson… - Cell Death & …, 2021 - nature.com
Human papillomaviruses (HPV) are a major cause of malignancy worldwide, contributing
to~ 5% of all human cancers including almost all cases of cervical cancer and a growing …

siRNA-E6 sensitizes HPV-16-related cervical cancer through Oxaliplatin: an in vitro study on anti-cancer combination therapy

P Shiri Aghbash, N Hemmat, B Baradaran… - European Journal of …, 2023 - Springer
Background Persistent infection with high-risk Human papillomaviruses (HPV), such as hr-
HPV-16 and hr-HPV-18, lead to cervical cancer, the fourth most common cancer in the …

HPV16 E6 promotes cell proliferation, migration, and invasion of human cervical cancer cells by elevating both EMT and stemness characteristics

YF Lu, Y Chen, ZY Zhang, MM Li… - Cell Biology …, 2022 - Wiley Online Library
In most cases of cervical cancer, the high risk of the disease is caused by the human
papilloma virus (HPV). Surgery or radiation usually benefits patients with early cervical …

HPV16E1 downregulation altered the cell characteristics involved in cervical cancer development

T Sasivimolrattana, A Chaiwongkot, P Bhattarakosol - Scientific Reports, 2023 - nature.com
The primary causes of cervical cancer are human papillomavirus type 16 (HPV16) and/or
other high-risk (Hr−) HPV infections. Hr-HPVE5, E6, and E7 have been identified as …

miR-2861 acts as a tumor suppressor via targeting EGFR/AKT2/CCND1 pathway in cervical cancer induced by human papillomavirus virus 16 E6

J Xu, X Wan, X Chen, Y Fang, X Cheng, X Xie, W Lu - Scientific reports, 2016 - nature.com
Persistent infection with oncogenic human papillomavirus viruses (HPVs) is a casual factor
for cervical cancer and its precursors and the abnormal constitutive expression of viral …

Signaling pathways in HPV‐associated cancers and therapeutic implications

J Chen - Reviews in medical virology, 2015 - Wiley Online Library
Human papillomaviruses (HPVs) are small double‐stranded circular DNA viruses with 8 kb
genomes. So far, more than 150 HPVs have been identified, and 12 types of HPVs have …

Human papillomavirus type 16 E7 promotes cell viability and migration in cervical cancer by regulating the miR-23a/HOXC8 axis

Y Chen, L Sun, L Li - Journal of Obstetrics and Gynaecology, 2024 - Taylor & Francis
Background Human papillomavirus (HPV) is a risk factor for the occurrence of cervical
cancer (CC). Here, we aimed to explore the role of HPV16 in CC and identify the underlying …

Clinical study of nimotuzumab combined with concurrent radiochemotherapy for treatment of locally advanced cervical cancer

W Chen, T Li, J Wang, L Liang, D Huang… - Cancer Management …, 2019 - Taylor & Francis
Purpose Nimotuzumab is a humanized monoclonal antibody that targets the epidermal
growth factor receptor (EGFR) to inhibit tumor growth. Nimotuzumab has demonstrated …

The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells

J Hu, D Liao, Z Sun, W Ren, L Zhao, Y Fang… - …, 2023 - academic.oup.com
Cervical cancer (CC) remains one of the most common female malignancies, with higher
incidence and mortality rates. more than 99% of CCs are associated with persistent infection …