Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing
H Wong, KC Yang, Y Shen… - Molecular …, 2018 - molecularcasestudies.cshlp.org
Pancreatic neuroendocrine tumors (PNETs) are a genomically and clinically heterogeneous
group of pancreatic neoplasms often diagnosed with distant metastases. Recurrent somatic …
group of pancreatic neoplasms often diagnosed with distant metastases. Recurrent somatic …
[HTML][HTML] Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary …
Y Jiang, Y Dong, S Zhao, D Liu, J Zhang, X Xu… - Cell Communication and …, 2024 - Springer
Pancreatic neuroendocrine tumors (PanNETs), though uncommon, have a high likelihood of
spreading to other body parts. Previously, the genetic diversity and evolutionary patterns in …
spreading to other body parts. Previously, the genetic diversity and evolutionary patterns in …
Genomic characterization of a well-differentiated grade 3 pancreatic neuroendocrine tumor
LM Williamson, M Steel… - Molecular …, 2019 - molecularcasestudies.cshlp.org
Pancreatic neuroendocrine neoplasms (PanNENs) represent a minority of pancreatic
neoplasms that exhibit variability in prognosis. Ongoing mutational analyses of PanNENs …
neoplasms that exhibit variability in prognosis. Ongoing mutational analyses of PanNENs …
Real-time genomic characterization of metastatic pancreatic neuroendocrine tumors has prognostic implications and identifies potential germline actionability
Purpose We assessed the usefulness of real-time molecular profiling through next-
generation sequencing (NGS) in predicting the tumor biology of advanced pancreatic …
generation sequencing (NGS) in predicting the tumor biology of advanced pancreatic …
Gene expression signatures identify novel therapeutics for metastatic pancreatic neuroendocrine tumors
Purpose: Pancreatic neuroendocrine tumors (pNETs) are uncommon malignancies noted for
their propensity to metastasize and comparatively favorable prognosis. Although both the …
their propensity to metastasize and comparatively favorable prognosis. Although both the …
[HTML][HTML] Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …
whose causation is only partly understood. An increasing number of studies have uncovered …
[HTML][HTML] Molecular biology of pancreatic neuroendocrine tumors: From mechanism to translation
X Shen, X Wang, X Lu, Y Zhao, W Guan - Frontiers in Oncology, 2022 - frontiersin.org
Pancreatic neuroendocrine tumors (pNETs) are a group of heterogeneous tumors originated
from progenitor cells. As these tumors are predominantly non-functional, most of them …
from progenitor cells. As these tumors are predominantly non-functional, most of them …
[HTML][HTML] Assessment of pancreatic neuroendocrine tumor cytologic genotype diversity to guide personalized medicine using a custom gastroenteropancreatic next …
Background Recent genetic studies have highlighted that alterations in MEN1, chromatin
remodeling genes, and mammalian target of rapamycin (mTOR) pathway genes are the …
remodeling genes, and mammalian target of rapamycin (mTOR) pathway genes are the …
[HTML][HTML] Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer
B Lawrence, C Blenkiron, K Parker, P Tsai… - NPJ genomic …, 2018 - nature.com
Pancreatic neuroendocrine tumors (pNETs) are uncommon cancers arising from pancreatic
islet cells. Here we report the analysis of gene mutation, copy number, and RNA expression …
islet cells. Here we report the analysis of gene mutation, copy number, and RNA expression …
[HTML][HTML] Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms
Pancreatic neuroendocrine neoplasms (PNENs) are biologically and clinically
heterogeneous. Here, we use a multi-omics approach to uncover the molecular factors …
heterogeneous. Here, we use a multi-omics approach to uncover the molecular factors …