Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing

H Wong, KC Yang, Y Shen… - Molecular …, 2018 - molecularcasestudies.cshlp.org
Pancreatic neuroendocrine tumors (PNETs) are a genomically and clinically heterogeneous
group of pancreatic neoplasms often diagnosed with distant metastases. Recurrent somatic …

[HTML][HTML] Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary …

Y Jiang, Y Dong, S Zhao, D Liu, J Zhang, X Xu… - Cell Communication and …, 2024 - Springer
Pancreatic neuroendocrine tumors (PanNETs), though uncommon, have a high likelihood of
spreading to other body parts. Previously, the genetic diversity and evolutionary patterns in …

Genomic characterization of a well-differentiated grade 3 pancreatic neuroendocrine tumor

LM Williamson, M Steel… - Molecular …, 2019 - molecularcasestudies.cshlp.org
Pancreatic neuroendocrine neoplasms (PanNENs) represent a minority of pancreatic
neoplasms that exhibit variability in prognosis. Ongoing mutational analyses of PanNENs …

Real-time genomic characterization of metastatic pancreatic neuroendocrine tumors has prognostic implications and identifies potential germline actionability

N Raj, R Shah, Z Stadler, S Mukherjee, J Chou… - JCO precision …, 2018 - ascopubs.org
Purpose We assessed the usefulness of real-time molecular profiling through next-
generation sequencing (NGS) in predicting the tumor biology of advanced pancreatic …

Gene expression signatures identify novel therapeutics for metastatic pancreatic neuroendocrine tumors

AT Scott, M Weitz, PJ Breheny, PH Ear, B Darbro… - Clinical Cancer …, 2020 - AACR
Purpose: Pancreatic neuroendocrine tumors (pNETs) are uncommon malignancies noted for
their propensity to metastasize and comparatively favorable prognosis. Although both the …

[HTML][HTML] Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets

CK Maharjan, PH Ear, CG Tran, JR Howe… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

[HTML][HTML] Molecular biology of pancreatic neuroendocrine tumors: From mechanism to translation

X Shen, X Wang, X Lu, Y Zhao, W Guan - Frontiers in Oncology, 2022 - frontiersin.org
Pancreatic neuroendocrine tumors (pNETs) are a group of heterogeneous tumors originated
from progenitor cells. As these tumors are predominantly non-functional, most of them …

[HTML][HTML] Assessment of pancreatic neuroendocrine tumor cytologic genotype diversity to guide personalized medicine using a custom gastroenteropancreatic next …

FC Gleeson, JS Voss, BR Kipp, SE Kerr… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background Recent genetic studies have highlighted that alterations in MEN1, chromatin
remodeling genes, and mammalian target of rapamycin (mTOR) pathway genes are the …

[HTML][HTML] Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer

B Lawrence, C Blenkiron, K Parker, P Tsai… - NPJ genomic …, 2018 - nature.com
Pancreatic neuroendocrine tumors (pNETs) are uncommon cancers arising from pancreatic
islet cells. Here we report the analysis of gene mutation, copy number, and RNA expression …

[HTML][HTML] Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms

KC Yang, SE Kalloger, JJ Aird, MKC Lee, C Rushton… - Cell reports, 2021 - cell.com
Pancreatic neuroendocrine neoplasms (PNENs) are biologically and clinically
heterogeneous. Here, we use a multi-omics approach to uncover the molecular factors …