Mechanisms of insulin resistance in subjects at risk for type 2 diabetes remain to be
elucidated. Insulin acts slowly in vivo, but rapidly in vitro, suggesting that the pathway insulin …

Impaired insulin sensitivity, also termed insulin resistance, is generally defined as reduced
glucose clearance in skeletal muscle, impaired suppression of glucose production by the …

The ability of large fat cells from spontaneously obese rats to synthesize fatty acids from D-[1-
14C] glucose, D-[6-14C] glucose, or [2-14C] pyruvate was markedly diminished compared to …

The concept of insulin resistance arose with the availability of insulin therapy for diabetes
mellitus. It soon became evident that diabetic patients could be divided into two groups …

We have studied glucose metabolism using large adipocytes isolated from older, fatterrats (>
12 months old,> 550 g), and smaller cells obtained from younger, leaner animals (4–5 …

Insulin resistance is often seen as a consequence of obesity and there are several possible
links between adipose tissue function and insulin resistance determined in other organs …

We have tested the hypothesis that in vitro exposure of insulin-resistant adipocytes with
insulin results in improved insulin action. A primary culture system of adipocytes from obese …

To evaluate the mechanism of insulin resistance in type 1 diabetes mellitus, we measured
insulin sensitivity in vivo and insulin action in adipocytes in vitro. The study groups consisted …

The term insulin resistance in humans is frequently used synonymous with impaired insulin-
stimulated glucose disposal (Moller et al., 1991; Garvey et al., 1993; Yki-Järvinen, 1994) as …

Obesity is associated with insulin resistance. Insulin resistance underlies a constellation of
adverse metabolic and physiological changes (the insulin resistance syndrome) which is a …