Abstract Purpose of Review Drug addiction starts from recreational drug use, gradually
becomes habitual or even compulsive. However, after exposure to addictive drugs, only …

Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …

Addiction is a notorious treatment-resistant psychiatric disorder characterized by the
impairment of self-monitoring, loss of interest in other targets of pleasure, and uncorrectable …

We revisit our hypothesis that drug addiction can be viewed as the endpoint of a series of
transitions from initial voluntarily drug use to habitual, and ultimately compulsive drug use …

Highlights•Development of drug seeking habits depends upon intrastriatal functional shifts.•
Endocannabinoid, opioid and adenosinergic systems control striatal plasticity.•These …

In this review we discuss the evidence that drug addiction, defined as a maladaptive
compulsive habit, results from the progressive subversion by addictive drugs of striatum …

Drug addiction is characterized in part by a lack of flexible control over drug-related
behaviors. This could be the result of strengthening drug-related habits or diminished goal …

Cocaine addiction is a complex and multidimensional process involving a number of
behavioral and neural forms of plasticity. The behavioral transition from voluntary drug use …

The reinforcing (rewarding) effects of psychomotor stimulants (cocaine and amphetamine)
depend on the mesocorticolimbic dopamine system innervating the nucleus accumbens …

Cocaine addiction is a complex and multifaceted process encompassing a number of forms
of behavioral plasticity. The process of acquiring and consuming drugs can be sufficiently …