Interface residues at sites of protein–protein interaction (PPI) are the focus for affinity
optimisation. However, protein hydrophobic cores (HCs) play critical roles and shape the …

MICA is a major histocompatibility complex-like protein that undergoes a structural transition
from disorder to order upon binding its immunoreceptor, NKG2D. We redesigned the …

We redesigned residues on the surface of MICA, a protein that binds the homodimeric
immunoreceptor NKG2D, to increase binding affinity with a series of rational, incremental …

Major Histocompatibility Complex class I-related chain molecules A (MICA) and receptor
Natural killer group 2 member D (NKG2D) are important membrane proteins with …

Background We previously developed a set of rationally designed mutant MICA protein
ligands for the NKG2D immunoreceptor in which MICA was mutated at residues that do not …

Major histocompatibility complex class I chain-related A and B (MICA/B) are cell-surface
proteins that act as ligands to natural killer cell receptors, NKG2D, expressed on immune …

Major histocompatibility complex (MHC) molecules are heterodimeric cell-surface receptors
that play a crucial role in the cellular immune response by presenting epitope peptides to T …

As an immune evasion strategy, MICA and MICB, the major histocompatibility complex class
I homologs, are proteolytically cleaved from the surface of cancer cells leading to impairment …

Poly-N-acylated amines, as a new class of synthetic non-peptide ligands for the murine
major histocompatibility complex (MHC) class I molecule H-2K b, were developed on the …

The immune system is engaged in a constant antigenic surveillance through the Major
Histocompatibility Complex (MHC) class I antigen presentation pathway. This is an efficient …