Hypoxia-inducible factor (HIF) is an oxygen-dependent transcription factor that activates a
diverse set of target genes, the products of which are involved in adaptive processes to …

In the lung, acute reductions in oxygen lead to hypoxic pulmonary vasoconstriction, whereas
prolonged exposures to hypoxia result in sustained vasoconstriction, pulmonary vascular …

Hypoxia-inducible transcription factors HIF-1α and HIF-2α can contribute to pulmonary
hypertension and vascular remodeling, but their mechanisms remain unknown. This study …

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls
transcriptional responses to hypoxia. HIF-1 plays critical roles both during development and …

Hypoxia-inducible factor (HIF)-1 is a transcription factor that is activated in response to
hypoxia and growth factor/cytokine signaling via regulation of the HIF-1α subunit. HIF-1 has …

Hypoxic pulmonary vasoconstriction is correlated with pulmonary vascular remodeling. The
hypoxia-inducible transcription factors (HIFs) HIF-1α and HIF-2α are known to contribute to …

Rationale: Chronic hypoxia induces pulmonary vascular remodeling, pulmonary
hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms …

The association between pulmonary hypertension (PH) and hypoxia is well-established,
with two key mechanistic processes, hypoxic pulmonary vasoconstriction and hypoxia …

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …

Chronic hypoxia induces pulmonary vascular remodeling, leading to pulmonary
hypertension, right ventricular hypertrophy, and heart failure. Heterozygous deficiency of …