Bitter taste receptor mTas2r105 is expressed in small intestinal villus and crypts

F Gu, X Liu, J Liang, J Chen, F Chen, F Li - Biochemical and biophysical …, 2015 - Elsevier
The small intestine is the most important digestion and absorption organ in the body. Taste
receptors and taste signal transduction cascades were detected in a variety of non-lingual …

Oligomerization of TAS2R bitter taste receptors

C Kuhn, B Bufe, C Batram, W Meyerhof - Chemical senses, 2010 - academic.oup.com
A family of 25 G protein–coupled receptors, TAS2Rs, mediates bitter taste in humans. Many
of the members of this family are coexpressed in a subpopulation of taste receptor cells on …

Do polymorphisms in chemosensory genes matter for human ingestive behavior?

JE Hayes, EL Feeney, AL Allen - Food quality and preference, 2013 - Elsevier
In the last decade, basic research in chemoreceptor genetics and neurobiology has
revolutionized our understanding of individual differences in chemosensation. From an …

[HTML][HTML] Bitter taste sensitivity is determined by TAS2R38 haplotype, associated with saturated fat intake and is lower in overweight and obese compared to normal …

L Pilic, CAM Graham, N Hares, M Brown, J Kean… - Current Developments …, 2020 - Elsevier
Objectives Taste perception (sensitivity) may be determined by genetic variations in taste
receptors and it affects food intake. Lower fat taste sensitivity is associated with higher …

Genetic and environmental determinants of bitter perception and sweet preferences

JA Mennella, MY Pepino, DR Reed - Pediatrics, 2005 - publications.aap.org
Objective. Flavor is the primary dimension by which young children determine food
acceptance. However, children are not merely miniature adults because sensory systems …

Analysis of the expression of human bitter taste receptors in extraoral tissues

A Jaggupilli, N Singh, J Upadhyaya… - Molecular and cellular …, 2017 - Springer
The 25 bitter taste receptors (T2Rs) in humans perform a chemosensory function. However,
very little is known about the level of expression of these receptors in different tissues. In this …

Association of TAS2R38 variants with sweet food intake in children aged 1–6 years

I Pawellek, V Grote, P Rzehak, A Xhonneux, E Verduci… - Appetite, 2016 - Elsevier
We aimed at studying whether genetic variants of the TAS2R38 gene are associated with
energy intake from sweet tasting foods, total energy and macronutrient intake and body …

Genetic variations of the bitter taste receptor TAS2R38 are associated with obesity and impact on single immune traits

FJ Ortega, Z Agüera, M Sabater… - Molecular Nutrition & …, 2016 - Wiley Online Library
Scope Changes in genetic variations affecting the taste receptor, type 2, member 38
(TAS2R38) may identify the interacting mechanism leading to obesity and potential …

Selection on the human bitter taste gene, TAS2R16, in Eurasian populations

H Li, AJ Pakstis, JR Kidd, KK Kidd - Human Biology, 2011 - BioOne
Bitter taste is one of the most important senses alerting humans to noxious foods. In gatherer
communities, sensitivity to bitterness is presumably advantageous because of various …

Amino acids and peptides activate at least five members of the human bitter taste receptor family

S Kohl, M Behrens, A Dunkel, T Hofmann… - Journal of agricultural …, 2013 - ACS Publications
Amino acids and peptides represent important flavor molecules eliciting various taste
sensations. Here, we present a comprehensive assessment of the interaction of various …