MHC-encoded molecules govern immune responses by presenting antigenic peptides to T-
cell receptors (TCRs). Several crystal structures of TCR–pMHC (peptide–MHC) complexes …

Crystal structures of 11 complexes of TCRs with peptide/MHC (pMHC), that represent 6
independent TCRs, constitute the current structural database for deriving general insights …

MHC-encoded molecules govern adaptive immune responses by presenting peptides to T
cell receptors (TCRs). Based on TCR–MHC crystal structures, we revisit the extent of TCR …

T cell receptor (TCR) recognition of peptide-MHC (pMHC) is central to the cellular immune
response. A large database of TCR–pMHC structures is needed to reveal general structural …

αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region
(CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged …

T cells are the master regulators of immune system function, continually walking the
biological tightrope between adequate host defence and accidental host pathology …

Antigen-dependent activation of T lymphocytes requires T cell receptor (TCR)-mediated
recognition of specific peptides, together with the MHC molecules to which they are bound …

T cells have to detect rare high-affinity 'foreign'peptide MHC (pMHC) ligands among
abundant low-affinity 'self'-peptide MHC ligands. It remains unclear how this remarkable …

Helper T lymphocytes play a critical role in immune system activation following recognition
of MHC class II-bound peptide ligands (pMHCII). These CD4 T cells stimulate B cell antibody …

The structural basis of antigen recognition in cellular immunity has been elucidated through
the determination of crystal structures of major histocompatibility complex (MHC) molecules …