Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel

J Jung, SW Hwang, J Kwak, SY Lee… - Journal of …, 1999 - Soc Neuroscience
Capsaicin (CAP) excites small sensory neurons, causing pain, neurogenic inflammation,
and other visceral reflexes. These effects have been proposed to be the result of CAP …

Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons

U Oh, SW Hwang, D Kim - Journal of Neuroscience, 1996 - Soc Neuroscience
Capsaicin (CAP), a neurotoxin, has been reported to activate a nonselective cation current
in dorsal root ganglion (DRG) neurons. In this paper, we identify and describe the properties …

Intracellular ATP increases capsaicin-activated channel activity by interacting with nucleotide-binding domains

J Kwak, MH Wang, SW Hwang, TY Kim… - Journal of …, 2000 - Soc Neuroscience
Capsaicin (CAP)-activated ion channel plays a key role in generating nociceptive neural
signals in sensory neurons. Here we present evidence that intracellular ATP upregulates the …

Sensory neuron-specific actions of capsaicin: mechanisms and applications

S Bevan, J Szolcsányi - Trends in Pharmacological sciences, 1990 - Elsevier
Capsaicin acts specifically on a subset of primary afferent sensory neurons to open cation-
selective ion channels, probably by interacting directly with a membrane receptor-ion …

A study of the voltage dependence of capsaicin‐activated membrane currents in rat sensory neurones before and after acute desensitization

AS Piper, JC Yeats, S Bevan… - The Journal of …, 1999 - Wiley Online Library
1 Responses to capsaicin in isolated sensory neurones have been shown to desensitize in
a Ca2+‐and voltage‐dependent manner. We have studied desensitization of capsaicin …

The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro

SJ Marsh, CE Stansfeld, DA Brown, R Davey… - Neuroscience, 1987 - Elsevier
The selective excitant and neurotoxic action of capsaicin on vagal sensory neurons in the rat
has been investigated in vitro using three techniques: extracellular recording of compound …

The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons

PA Koplas, RL Rosenberg, GS Oxford - Journal of Neuroscience, 1997 - Soc Neuroscience
Capsaicin (Cap) is a pungent extract of the Capsicum pepper family, which activates
nociceptive primary sensory neurons. Inward current and membrane potential responses of …

Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats

RJ Docherty, JC Yeats, S Bevan, H Boddeke - Pflügers Archiv, 1996 - Springer
Capsaicin activates a non-specific cation conductance in mammalian sensory neurones. If
capsaicin is applied continuously or repeatedly then there is a progressive decline in …

Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats

L Vyklický, H Knotková-Urbancová… - Journal of …, 1998 - journals.physiology.org
Vyklický, Ladislav, Helena Knotková-Urbancová, Zdeňka Vitásková, Viktorie Vlachová,
Michaela Kress, and Peter W. Reeh. Inflammatory mediators at acidic pH activate capsaicin …

Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons

L Liu, M Oortgiesen, L Li… - Journal of …, 2001 - journals.physiology.org
Capsaicin, the pungent ingredient in hot pepper, activates nociceptors to produce pain and
inflammation. However, repeated exposures of capsaicin will cause desensitization to …