INTRODUCTION: 68Ga-labeled RGD peptides in combination with PET allow non-invasive
determination of αvβ3 integrin expression which is highly increased during tumor-induced …

The overexpression of integrin αvβ3 has been linked to tumor aggressiveness and
metastasis in several cancer types. Because of its high affinity, peptides containing the …

Purpose Angiogenesis plays an important role in the growth and metastatic spread of solid
tumours and is characterised by the expression of integrins on the cell surface of endothelial …

The integrin αvβ3 receptor is upregulated on tumor cells and endothelium and plays
important roles in angiogenesis and metastasis. Arg-Gly-Asp (RGD) peptide ligands have …

Purpose Molecular imaging using positron emission tomography (PET) radiotracers targeted
to tumor vasculature offers a noninvasive method for early detection of tumor angiogenesis …

Peptides containing the Arg-Gly-Asp (RGD) sequence have high affinity for αvβ3 integrin
receptors overexpressed in tumor cells. The objective of this research was to determine the …

Vascular endothelial growth factor receptor (VEGFR) and integrin αv are over-expressed in
angiogenesis of variety malignant tumors with key roles in angiogenesis, and have been …

In vivo imaging of αvβ3 expression has important diagnostic and therapeutic applications.
Multimeric cyclic RGD peptides are capable of improving the integrin αvβ3–binding affinity …

Integrin αvβ3 plays a significant role in tumor angiogenesis and is a receptor for the
extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide …

To date, the in vivo imaging of quantum dots (QDs) has been mostly qualitative or
semiquantitative. The development of a dual-function PET/near-infrared fluorescence (NIRF) …