One-carbon metabolism is a key metabolic network that integrates nutritional signals with
embryonic development. However, the response of one-carbon metabolism to methionine …

Objectives Early pregnancy loss is a major clinical concern in animal and human
reproduction, which is largely influenced by embryo implantation. The importance of …

One carbon metabolism or methyl transfer, a crucial component of metabolism in all cells
and tissues, supports the critical function of synthesis of purines, thymidylate and …

Background Embryonic and fetal development is very susceptible to the availability of
nutrients that can interfere with the setting of epigenomes, thus modifying the main metabolic …

During early development, both genome‐wide epigenetic reprogramming and metabolic
remodeling are hallmark changes of normal embryogenesis. However, little is known about …

During development, a fetus and its placenta must respond to a changing maternal
environment to ensure normal growth is achieved and survival is maintained. The …

Abstract The Developmental Origins of Health and Disease hypothesis sustains that
exposure to different stressors during prenatal development prepares the offspring for the …

Human (h) and mouse (m) embryonic stem (ES) cells need specific amino acids to
proliferate. mES cells require threonine (Thr) metabolism for epigenetic histone …

Beyond energy production, nutrient metabolism plays a crucial role in stem cell lineage
determination. Changes in metabolism based on nutrient availability and dietary habits …

Methionine adenosyltransferase (MAT) is involved in folate-mediated one-carbon
metabolism, which is essential for preimplantation embryos in terms of both short-term …