Protective effect of a novel herbmedicine, Hepad, on apoptosis of SH-SY5Y cells and a rat model of Parkinson's disease

SY Baek, NR Lee, DH Kim, A Gu, SY Kim… - Molecular & Cellular …, 2015 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons in the substantia nigra pars compacta. In this study, we investigated …

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson's Disease: Involvement of the PI3K/Akt/GSK3β Pathway

W Zhang, H He, H Song, J Zhao, T Li, L Wu… - Parkinson's …, 2016 - Wiley Online Library
The degenerative loss through apoptosis of dopaminergic neurons in the substantia nigra
pars compacta plays a primary role in the progression of Parkinson's disease (PD). Our in …

[HTML][HTML] Herbal medicine (Hepad) prevents dopaminergic neuronal death in the rat MPTP model of Parkinson's disease

DH Kim, JJ Choi, BJ Park - Integrative Medicine Research, 2019 - Elsevier
Background Parkinson's disease (PD) is a neurodegenerative disorder characterized by
loss of dopaminergic neurons in the substantia nigra. The purpose of this study was to …

Effect of a Traditional Chinese Herbal Medicine Formulation on Cell Survival and Apoptosis of MPP+‐Treated MES 23.5 Dopaminergic Cells

S Ye, HK Koon, W Fan, Y Xu, W Wei, C Xu… - Parkinson's …, 2017 - Wiley Online Library
Progressive degeneration of dopaminergic neurons in the substantia nigra (SN) is
implicated in Parkinson's disease (PD). The efficacy of these currently used drugs is limited …

Neuroprotective Effects of Gagam‐Sipjeondaebo‐Tang, a Novel Herbal Formula, against MPTP‐Induced Parkinsonian Mice and MPP+‐Induced Cell Death in SH …

JH Ko, JH Lee, B Choi, JY Park… - Evidence‐Based …, 2018 - Wiley Online Library
Parkinson's disease is a neurodegenerative disease characterized by progressive cell death
of dopaminergic neuron and following neurological disorders. Gagam‐Sipjeondaebo‐Tang …

[HTML][HTML] Mitigation effects of a novel herbal medicine, hepad, on neuroinflammation, neuroapoptosis, and neuro-oxidation

DH Song, GJ Kim, KJ Lee, JS Shin, DH Kim, BJ Park… - Molecules, 2018 - mdpi.com
Parkinson's disease (PD), a common adult-onset neurodegenerative disorder with complex
pathological mechanisms, is characterized by the degeneration of dopaminergic …

Neuroprotective effect of hydroxysafflor yellow A on 6-hydroxydopamine-induced Parkinson's disease in rats

B Han, J Hu, J Shen, Y Gao, Y Lu, T Wang - European journal of …, 2013 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting
predominantly the dopaminergic mesotelencephalic system. Enormous progress has been …

Protective effects of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d-glucoside in the MPTP-induced mouse model of Parkinson's disease: Involvement of reactive oxygen …

H He, S Wang, J Tian, L Chen, W Zhang, J Zhao… - European Journal of …, 2015 - Elsevier
Parkinson's disease (PD) is characterized by the selective death of dopaminergic neurons in
the substantia nigra pars compacta. Oxidative stress-induced neuron loss is thought to play …

Regulation of AKT/AMPK signaling, autophagy and mitigation of apoptosis in Rutin-pretreated SH-SY5Y cells exposed to MPP+

AB Enogieru, W Haylett, DC Hiss, OE Ekpo - Metabolic Brain Disease, 2021 - Springer
Accumulating evidence suggest that apoptosis, autophagy and dysregulation of signaling
pathways are common mechanisms involved in Parkinson's disease (PD) pathogenesis …

Carnosic acid protects SH-SY5Y cells against 6-hydroxydopamine-induced cell death through upregulation of parkin pathway

CY Lin, CW Tsai - Neuropharmacology, 2016 - Elsevier
Parkin is a Parkinson's disease (PD)-linked gene that plays an important role in the ubiquitin-
proteasome system (UPS). This study explored whether carnosic acid (CA) from rosemary …