Comparison of the Biological Basis for Non-HIV Transmission to HIV-Exposed Seronegative Individuals, Disease Non-Progression in HIV Long-Term Non …

J Hokello, P Tyagi, S Dimri, AL Sharma, M Tyagi - Viruses, 2023 - mdpi.com
HIV-exposed seronegative individuals (HESIs) are a small fraction of persons who are
multiply exposed to human immunodeficiency virus (HIV), but do not exhibit serological or …

[HTML][HTML] Viral factors in non-progression

B Wang - Frontiers in immunology, 2013 - frontiersin.org
Research has undergone considerable development in understanding a small subset of
human immunodeficiency virus type 1 (HIV-1)-infected, therapy-naive individuals who …

Natural control of HIV-1 replication and long-term nonprogression: overlapping but distinct phenotypes

PW Hunt - The Journal of infectious diseases, 2009 - academic.oup.com
With 133 million individuals infected with human immunodeficiency virus type 1 (HIV-1)
worldwide, and with 12 million more individuals infected every year [1], the need for an …

HIV controllers: a genetically determined or inducible phenotype?

A Sáez‐Cirión, G Pancino - Immunological reviews, 2013 - Wiley Online Library
Summary Less than 0.5% of human immunodeficiency virus‐1 (HIV‐1)‐infected patients
maintain viral load below the threshold of detection by conventional assays for many years …

Factors leading to the loss of natural elite control of HIV-1 infection

M Pernas, L Tarancon-Diez… - Journal of …, 2018 - Am Soc Microbiol
ABSTRACT HIV-1 elite controllers (EC) maintain undetectable viral loads (VL) in the
absence of antiretroviral treatment. However, these subjects have heterogeneous clinical …

[PDF][PDF] Mechanisms involved in non-progressive HIV disease

M Mikhail, B Wang, NK Saksena - AIDS Rev, 2003 - researchgate.net
HIV disease is a culmination of a complex interplay between both viral and host factors. As
the underlying biological and molecular mechanisms involved in determining disease status …

[PDF][PDF] Elite HIV controllers: myth or reality

NK Saksena, B Rodes, B Wang, V Soriano - AIDS Rev, 2007 - researchgate.net
Despite the varying disease progression rates, the majority of HIV-infected individuals
eventually progress to AIDS. There is a subset of HIV-positive individuals, who maintain high …

HIV-2 as a model to identify a functional HIV cure

J Esbjörnsson, M Jansson, S Jespersen… - AIDS research and …, 2019 - Springer
Two HIV virus types exist: HIV-1 is pandemic and aggressive, whereas HIV-2 is confined
mainly to West Africa and less pathogenic. Despite the fact that it has been almost 40 years …

Unravelling the mechanisms of durable control of HIV-1

BD Walker, XG Yu - Nature reviews Immunology, 2013 - nature.com
Untreated HIV-1 infection typically progresses to AIDS within 10 years, but less than 1% of
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …

The implications of viral reservoirs on the elite control of HIV-1 infection

RW Buckheit III, M Salgado, KO Martins… - Cellular and molecular …, 2013 - Springer
The mechanisms by which a small percentage of HIV-1 infected individuals known as elite
suppressors or controllers are able to control viral replication are not fully understood. Early …