The regulatory 2D in vitro micronucleus (MN) assay is part of a battery of tests, used to test
for genotoxicity of new and existing compounds before they are assessed in vivo (ICH S2) …

Micronucleus (MN) assessment is a valuable tool in safety assessment. However, several
compounds are positive in the in vivo bone marrow (BM) MN assay but negative in vitro …

The toxicological relevance of the micronucleus (MN) test is well defined: it is a multi-target
genotoxic endpoint, assessing not only clastogenic and aneugenic events but also some …

In vivo genotoxicity tests play a pivotal role in genotoxicity testing batteries. They are used
both to determine if potential genotoxicity observed in vitro is realised in vivo and to detect …

In vitro test batteries have become the standard approach to determine the genotoxic
potential of substances of interest across industry sectors. While useful for hazard …

Micronucleus (MN) induction is an established cytogenetic end point for evaluating structural
and numerical chromosomal alterations in genotoxicity testing. A semi-automated scoring …

Children with Down syndrome are at elevated risk (10-20-fold) for the development of
leukemia. The DS-myeloid leukemia (DS-ML) treatment relies largely on low-dose …

The in vitro micronucleus (MN) assay is a component of most test batteries used in
assessing potential genotoxicity. Our previous study adapted metabolically competent …

In this article, the relationship was studied between the in vivo mutagenicity assay of mouse
bone marrow micronucleus (MIC), and four in vitro assays: Salmonella typhimurium …

Highlights•The bone marrow microenvironment protects leukaemia stem cells against
therapeutic drugs.•3D ex vivo co-culture models advance translational AML research.•3D ex …