Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of
plasma cells in the bone marrow (BM), which remains incurable because most patients …

Abstract The Organisation for Economic Co-operation and Development (OECD) endorses
test guidelines (TG) for identifying chemicals that are genotoxic, such as the transgenic …

This study presents a high-throughput (HTP) micronucleus assay in multi-well plates with an
automated evaluation for risk assessment applications. The evaluation of genotoxicity via …

Many conventional in vitro tests that are currently widely used for routine screening of
chemicals have a sensitivity/specificity in the range between 60% and 80% for the detection …

The in vitro micronucleus (IVMN) test was endorsed for regulatory genotoxicity testing with
adoption of the Organisation for Economic Co-operation and Development (OECD) test …

Positive results in the Ames test correlate well with carcinogenic potential in rodents. This
correlation is not perfect because mutations are only one of many stages in tumour …

In the third collaborative study organized by the Collaborative Study Group for the
Micronucleus Test (CSGMT), a task group belonging to the Mammalian Mutagenesis Study …

Although the target cells for the bone marrow (BM) and peripheral blood (PB) micronucleus
tests are the same, erythroblasts, the PB method offers important advantages over the BM …

Background The in vitro micronucleus (MN) test is an important component of a genotoxicity
test battery that evaluates chemicals. Although the standard method of manually scoring …