Hypoxia, the typical and conspicuous characteristic of most solid tumors, worsens the tumor
invasiveness and metastasis. Here, we engineered a sequential ultrasound (US)/hypoxia …

Sonodynamic therapy (SDT), which uses reactive oxygen species to target tumors, has
shown promise in the management of unresectable cancers. However, the hypoxic tumor …

The hypoxic microenvironment induced by sonodynamic therapy (SDT) via sonochemical
oxygen consumption usually triggered tumor resistance to SDT, impeding therapeutic …

Ultrasound (US)-triggered sonodynamic therapy (SDT) is an emerging method for treating
cancer due to its non-invasive nature and high-depth tissue penetration ability. However …

Hypoxia as one characteristic hallmark of solid tumors has been demonstrated to be
involved in cancer metastasis and progression, induce severe resistance to oxygen …

The hypoxic tumor microenvironment (TME) and non-specific distribution of sonosensitizers
are two major obstacles that limit practical applications of sonodynamic therapy (SDT) in …

Novel sonosensitizers with intrinsic characteristics for tumor diagnosis, efficient therapy, and
tumor microenvironment regulation are appealing in current sonodynamic therapy. Herein, a …

Sonodynamic therapy (SDT) is noninvasive and possesses high body‐penetration depth,
showing great potential for the treatment of deep‐seated solid tumors. The efficacy of SDT …

The further bioapplications of sonodynamic therapy (SDT) were hindered by the inadequate
efficiency and poor degradability of sonosensitizers and the hypoxic tumor …

Ultrasound (US)-triggered sonodynamic therapy (SDT) can solve the critical issue of low
tissue-penetrating depth of traditional phototriggered therapies, but the SDT efficacy is still …