Hypoxia-inducible factor-1α (HIF-1α) is widely distributed in human cells, and it can form
different signaling pathways with various upstream and downstream proteins, mediate …

Abstract Hypoxia-inducible factor 1 (HIF-1), as a main transcriptional regulator of metabolic
adaptation to changes in the oxygen environment, participates in many physiological and …

Abstract Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master
regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that …

Tumor hypoxia has been recognized as a common feature of solid tumors and a negative
prognostic factor for response to treatment and survival of cancer patients. The discovery of …

The discovery of hypoxia‐inducible factor‐1 (HIF‐1) has led to an increasing understanding
of the mechanism of tumor hypoxia in the past two decades. As a key transcriptional …

Tumor hypoxia is a common feature in most solid tumors and is associated with
overexpression of the hypoxia response pathway. Overexpression of the hypoxia‐inducible …

The discovery of hypoxia-inducible factor-1 has led to a rapidly increasing understanding of
the molecular mechanism of tumor hypoxia in the past two decades. Today it is generally …

Abstract Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator,
which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer
drug target. Many recent studies have provided convincing evidences of strong correlation …

The hypoxia-inducible factor-1 (HIF-1) is a key regulator in the mammalian response to
oxygen deficiency under both physiological and pathological conditions such as cancer. A …