Rho kinase inhibitors: a patent review (2014–2016)
O Defert, S Boland - Expert opinion on therapeutic patents, 2017 - Taylor & Francis
ABSTRACT Introduction: The Rho-kinases (ROCK), ROCK1 and ROCK2, are potent,
widespread biochemical modulators which have been extensively studied. Due to the …
widespread biochemical modulators which have been extensively studied. Due to the …
Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries
N Sawada, H Itoh, K Ueyama, J Yamashita, K Doi… - Circulation, 2000 - Am Heart Assoc
Background—Rho-associated kinase (ROCK), an effector of small GTPase Rho, regulates
vascular tone via a calcium sensitization mechanism and plays a key role in the …
vascular tone via a calcium sensitization mechanism and plays a key role in the …
Rho/Rho kinase signal transduction pathway in cardiovascular disease and cardiovascular remodeling
The small guanosine triphosphatase Rho and its target, Rho kinase, play important roles in
both blood pressure regulation and vascular smooth muscle contraction. Rho is activated by …
both blood pressure regulation and vascular smooth muscle contraction. Rho is activated by …
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury
K Noma, Y Rikitake, N Oyama, G Yan… - The Journal of …, 2008 - Am Soc Clin Investig
Although Rho-associated kinase (ROCK) activity has been implicated in cardiovascular
diseases, the tissue-and isoform-specific roles of ROCKs in the vascular response to injury …
diseases, the tissue-and isoform-specific roles of ROCKs in the vascular response to injury …
Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy
The development of left ventricular cardiomyocyte hypertrophy in response to increased
hemodynamic load and neurohormonal stress is initially a compensatory response …
hemodynamic load and neurohormonal stress is initially a compensatory response …
Rho-associated kinase activity, endothelial function, and cardiovascular risk factors
J Soga, K Noma, T Hata, T Hidaka, Y Fujii… - … , and vascular biology, 2011 - Am Heart Assoc
Objective—Cardiovascular diseases are associated with chronic activation of Rho-
associated kinases (ROCKs) and endothelial dysfunction. Both increased ROCK activity and …
associated kinases (ROCKs) and endothelial dysfunction. Both increased ROCK activity and …
Advances in the development of Rho-associated protein kinase (ROCK) inhibitors
Highlights•The structures and therapeutic importance of ROCK are outlined.•The available
inhibitors of ROCK are summarized.•The binding mechanisms of representative ROCK …
inhibitors of ROCK are summarized.•The binding mechanisms of representative ROCK …
Regulation of Rho proteins by phosphorylation in the cardiovascular system
The small G protein Rho signaling pathways are recognized as major regulators of
cardiovascular functions, and activation of Rho proteins appears to be a common …
cardiovascular functions, and activation of Rho proteins appears to be a common …
ROCK2 regulates monocyte migration and cell to cell adhesion in vascular endothelial cells
Y Takeda, K Matoba, D Kawanami, Y Nagai… - International journal of …, 2019 - mdpi.com
The small GTPase Rho and its downstream effector, Rho-kinase (ROCK), regulate various
cellular functions, including organization of the actin cytoskeleton, cell adhesion and …
cellular functions, including organization of the actin cytoskeleton, cell adhesion and …
ROCK in CNS: different roles of isoforms and therapeutic target for neurodegenerative disorders
CM Chong, N Ai, S Ming-Yuen Lee - Current drug targets, 2017 - ingentaconnect.com
Rho-associated protein kinase (ROCK) is a serine-threonine kinase originally identified as a
crucial regulator of actin cytoskeleton. Recent studies have defined new functions of ROCK …
crucial regulator of actin cytoskeleton. Recent studies have defined new functions of ROCK …