Subclinical infections that serve as reservoir populations to drive transmission remain a
hurdle to malaria control. Data on infection dynamics in a geographical area is required to …

Introduction Naturally acquired immune responses against antigens expressed on the
surface of mature gametocytes develop in individuals living in malaria-endemic areas …

Malaria elimination efforts would benefit from vaccines that block transmission of
Plasmodium falciparum gametocytes from humans to mosquitoes. A clear understanding of …

The recent decline in global malaria burden has stimulated efforts toward Plasmodium
falciparum elimination. Understanding the biology of malaria transmission stages may …

Individuals infected with P. falciparum develop antibody responses to intra-erythrocytic
gametocyte proteins and exported gametocyte proteins present on the surface of infected …

Vaccines that target Plasmodium falciparum gametocytes have the potential to reduce
malaria transmission and are thus attractive targets for malaria control. However, very little is …

Malaria transmission depends on the presence of Plasmodium gametocytes that are the
only parasite life stage that can infect mosquitoes. Gametocyte production varies between …

Background Epidemiological studies indicate that some children experience many more
episodes of clinical malaria than their age mates in a given location. Whether this is as a …

Background Natural immunity to Plasmodium falciparum has been widely studied, but its
effects on parasite dynamics are poorly understood. Acquisition and clearance rates of …

Plasmodium falciparum infections in low-transmission settings are often asymptomatic with
low parasite densities despite low herd immunity. Based on studies in Zanzibar, this may be …