Liver disorders are a major health concern. Saikosaponin-d (SSd) is an effective active
ingredient extracted from Bupleurum falcatum, a traditional Chinese medicinal plant, with …

Abstract Background Radix Bupleuri (RB) has been popularly used for treating many liver
diseases such as chronic hepatic inflammation and viral Hepatitis in China. Increasing …

Overdose of acetaminophen (APAP) can cause acute liver injury that is sometimes fatal,
requiring efficient pharmacological intervention. The traditional Chinese herb Bupleurum …

Nonalcoholic fatty liver disease (NAFLD) has become one of the most prominent causes of
chronic liver diseases and malignancies. However, few therapy has been approved. Radix …

Saikosaponin‑d (SSd) the primary active component of triterpene saponin derived from
Bupleurum falcatum L., possesses anti‑inflammatory and antioxidant properties. The present …

Ethnopharmacological relevance Hyperlipidemia is the systemic manifestation of abnormal
lipid metabolism, characterized by elevated circulating levels of cholesterol and triglyceride …

Saikosaponin a (SSa), one of the major active components of Bupleurum falcatum, has
antioxidant and anti-inflammatory pharmacological properties. However, the effects of SSa …

NLRP3 inflammasome activation results in severe liver inflammation and injury.
Saikosaponin-d (SSd) possesses anti-inflammatory and hepatoprotective effects. This study …

Treatment of liver fibrosis and cirrhosis remains a challenging field. Hepatocyte injury and
the activation of hepatic stellate cells are the 2 major events in the development of liver …

Background Metabolic associated fatty liver disease (MAFLD) is a progressive chronic liver
disease, yet there is still a lack of effective pharmacological therapies at present …